Mussel-Inspired Chemistry for Robust and Surface-Modifiable Multilayer Films
Mussel-Inspired Chemistry for Robust and Surface-Modifiable Multilayer Films
复制标题
受贻贝启发的化学方法，用于坚固且表面可改性的多层薄膜
DOI：
10.1021/la2027237
复制
发表时间：
2011-11-15
期刊：
影响因子：
3.9
通讯作者：
Xu, Jian
中科院分区：
文献类型：
--
作者：
Wu, Junjie;Zhang, Liang;Xu, Jian
In this article, we report a bioinspired approach to preparing stable, functional multilayer films by the integration of mussel-inspired catechol oxidative chemistry into a layer-by-layer (LbL) assembly. A polyanion of poly(acrylic acid-g-dopamine) (PAA-dopamine) bearing catechol groups, a mussel adhesive protein-mimetic polymer, was synthesized as the building block for LbL assembly with poly(allylamine hydrochloride) (PAH). The oxidization of the incorporated catechol group under mild oxidative condition yields o-quinone, which exhibits high reactivity with amine and catechol, thus endowing the chemical covalence and retaining the assembled morphology of multilayer films. The cross-linked films showed excellent stability even in extremely acidic, basic, and highly concentrated aqueous salt solutions. The efficient chemical cross-linking allows for the production of intact free-standing films without using a sacrificial layer. Moreover, thiol-modified multilayer films with good stability were exploited by a combination of thiols-catechol addition and then oxidative cross-linking. The outstanding stability under harsh conditions and the facile functionalization of the PAA-dopamine/PAH multilayer films make them attractive for barriers, separation, and biomedical devices.
