Epidemiology of childhood IDDM in U.S. Virgin Islands from 1979 to 1988: Evidence of an Epidemic in Early 1980s and Variation by Degree of Racial Admixture
Epidemiology of childhood IDDM in U.S. Virgin Islands from 1979 to 1988: Evidence of an Epidemic in Early 1980s and Variation by Degree of Racial Admixture
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1979 年至 1988 年美属维尔京群岛儿童 IDDM 的流行病学：20 世纪 80 年代初流行的证据以及种族混合程度的变化
DOI：
10.2337/diacare.14.7.558
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发表时间：
1991
期刊：
影响因子：
16.2
通讯作者：
C. Christian
中科院分区：
文献类型：
--
作者：
E. Tull;J. Roseman;C. Christian
目的对美属维尔京群岛以黑人为主的人群中胰岛素依赖型糖尿病（IDDM）的流行病学进行评价。研究设计和方法通过回顾性分析医院和诊所记录初步确定糖尿病受试者，并根据糖尿病流行病学研究国际组标准定义IDDM。结果1979-1988年，28例15岁以下儿童被诊断为IDDM，平均年发病率为7.5 scin 100，000（95%可信区间4.7-10.3）。当1984年IR上升到28.4 scin 100，000时，观察到IDDM发病率显著增加（P < 0.01）。白色儿童的IR最高（28.9 scin 100，000）。西班牙裔的IR（7.2 scin 100，000）略高于黑人（5.9 scin 100，000）。在黑人儿童中，观察到男性的发病率略高，但不显著（男女比为1.5）。当将黑人或西班牙裔患者与年龄匹配的对照组的祖父母种族进行比较时，糖尿病受试者的白色血统百分比更高（分别为P < 0.02和P < 0.05）。在加勒比黑人（西印度群岛）在美属维尔京群岛的胰岛素依赖型糖尿病的发病率是类似的黑人在美国的结论在1984年的胰岛素依赖型糖尿病的流行提供了支持，在20世纪80年代初可能的大流行。
Objective The epidemiology of insulin-dependent diabetes mellitus (IDDM) was evaluated in a predominantly black population in the U.S. Virgin Islands. Research Design and Methodsd Primary ascertainment of diabetic subjects was by retrospective review of hospital and clinic records, and IDDM was defined by Diabetes Epidemiology Research International Group criteria. Results For the period 1979–1988, 28 children < 15 yr of age were diagnosed with IDDM resulting in an average annual IDDM incidence rate (IR) of 7.5∕100,000 (95% confidence interval 4.7–10.3). A significant increase in IDDM incidence (P < 0.01) was observed when the IR rose to 28.4∕100,000 in 1984. White children had the highest IR (28.9∕100,000). The IR for Hispanics (7.2∕100,000) was slightly higher than that for blacks (5.9∕100,000). Among black children, a slight but nonsignificant male excess in incidence was observed (male-female ratio 1.5). When black or Hispanic patients were compared with age-matched control subjects with respect to grandparental race, the diabetic subjects had a greater percentage of white ancestry (P < 0.02 and P < 0.05, respectively). The incidence of IDDM in Caribbean blacks (West Indians) in the U.S. Virgin Islands was similar to blacks in the U.S. Conclusions The epidemic of IDDM in 1984 provides support for a possible pandemic in the early 1980s.
影响因子：
158.5
作者：
WINTER, WE;MACLAREN, NK;SPILLAR, RP
通讯作者：
SPILLAR, RP