Antigenic Mapping of the Hemagglutinin of an H9N2 Avian Influenza Virus Reveals Novel Critical Amino Acid Positions in Antigenic Sites
Antigenic Mapping of the Hemagglutinin of an H9N2 Avian Influenza Virus Reveals Novel Critical Amino Acid Positions in Antigenic Sites
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DOI：
10.1128/jvi.03440-13
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发表时间：
2014-04-01
影响因子：
5.4
通讯作者：
Qin, Aijian
中科院分区：
文献类型：
--
作者：
Wan, Zhimin;Ye, Jianqiang;Qin, Aijian
H9N2流感病毒正在经历广泛的遗传和抗原进化，有必要对其血凝素（HA）进行详细的抗原定位。通过检测亚洲禽流感H9N2病毒的抗体逃逸突变体，我们确定了H9抗原位点的9个关键氨基酸位置。其中5个位点（164、167、168、196和207）以前未被报道过，因此，它们代表了监测H9N2病毒抗原变化的新分子标记。
H9N2 influenza virus is undergoing extensive genetic and antigenic evolution, warranting detailed antigenic mapping of its hemagglutinin (HA). Through examining antibody escape mutants of an Asian avian H9N2 virus, we identified 9 critical amino acid positions in H9 antigenic sites. Five of these positions, 164, 167, 168, 196, and 207, have not been reported previously and, thus, represent novel molecular markers for monitoring the antigenic change of H9N2 virus.