A placebo-controlled trial of prucalopride for severe chronic constipation
A placebo-controlled trial of prucalopride for severe chronic constipation
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DOI：
10.1056/nejmoa0800670
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发表时间：
2008-05-29
影响因子：
158.5
通讯作者：
Vandeplassche, Lieve
中科院分区：
文献类型：
--
作者：
Camilleri, Michael;Kerstens, Rene;Vandeplassche, Lieve
背景资料：在这项为期12周的试验中，我们旨在确定普卢卡必利（一种选择性、高亲和力的5-羟色胺（sub 4）受体激动剂）对严重慢性便秘患者的疗效。
Background: In this 12-week trial, we aimed to determine the efficacy of prucalopride, a selective, high-affinity 5-hydroxytryptamine(sub 4) receptor agonist, in patients with severe chronic constipation.Methods: In our multicenter, randomized, placebo-controlled, parallel-group, phase 3 trial, patients with severe chronic constipation (