Population genomic evidence of Plasmodium vivax Southeast Asian origin.
Population genomic evidence of Plasmodium vivax Southeast Asian origin.
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DOI：
10.1126/sciadv.abc3713
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发表时间：
2021-04
期刊：
影响因子：
13.6
通讯作者：
Rougeron V
中科院分区：
文献类型：
--
作者：
Daron J;Boissière A;Boundenga L;Ngoubangoye B;Houze S;Arnathau C;Sidobre C;Trape JF;Durand P;Renaud F;Fontaine MC;Prugnolle F;Rougeron V
447株间日疟原虫在世界范围内的遗传多样性特征显示东南亚起源的证据。间日疟原虫是最常见、分布最广的人类疟疾寄生虫。最近有人提出，间日疟原虫起源于撒哈拉以南非洲，这是基于其最近的遗传亲缘（间日疟原虫样）在非洲类人猿中的传播。然而，有限数量的遗传标记和样本调查质疑这一假设的稳健性。在这里，我们广泛表征了447个人类间日疟原虫毒株和19个类人猿间日疟原虫样毒株的基因组变异。人类和类人猿疟原虫之间的系统发育关系表明间日疟原虫是间日疟原虫样的一个姐妹分支，不包括在间日疟原虫样的辐射范围内。通过研究间日疟原虫遗传变异的各个方面，我们在汇总统计中发现了与东南亚地理距离增加的几个显著的地理模式，表明间日疟原虫可能是通过一系列的创始人效应从亚洲的一个地区衍生而来的。
Characterization of the worldwide genetic diversity of 447 P. vivax strains shows evidence for a Southeast Asian origin. Plasmodium vivax is the most common and widespread human malaria parasite. It was recently proposed that P. vivax originates from sub-Saharan Africa based on the circulation of its closest genetic relatives (P. vivax-like) among African great apes. However, the limited number of genetic markers and samples investigated questions the robustness of this hypothesis. Here, we extensively characterized the genomic variations of 447 human P. vivax strains and 19 ape P. vivax-like strains collected worldwide. Phylogenetic relationships between human and ape Plasmodium strains revealed that P. vivax is a sister clade of P. vivax-like, not included within the radiation of P. vivax-like. By investigating various aspects of P. vivax genetic variation, we identified several notable geographical patterns in summary statistics in function of the increasing geographic distance from Southeast Asia, suggesting that P. vivax may have derived from a single area in Asia through serial founder effects.
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影响因子：
3.7
作者：
Auburn S;Marfurt J;Maslen G;Campino S;Ruano Rubio V;Manske M;Machunter B;Kenangalem E;Noviyanti R;Trianty L;Sebayang B;Wirjanata G;Sriprawat K;Alcock D;Macinnis B;Miotto O;Clark TG;Russell B;Anstey NM;Nosten F;Kwiatkowski DP;Price RN
通讯作者：
Price RN
影响因子：
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作者：
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通讯作者：
Otto, Thomas D
影响因子：
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作者：
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Price, Ric N.
影响因子：
4.4
作者：
Chen SB;Wang Y;Kassegne K;Xu B;Shen HM;Chen JH
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Chen JH
影响因子：
6.4
作者：
Cowell AN;Loy DE;Sundararaman SA;Valdivia H;Fisch K;Lescano AG;Baldeviano GC;Durand S;Gerbasi V;Sutherland CJ;Nolder D;Vinetz JM;Hahn BH;Winzeler EA
通讯作者：
Winzeler EA