Crossreactive neutralizing antibodies induced by immunization with caprine arthritis-encephalitis virus surface glycoprotein.
Crossreactive neutralizing antibodies induced by immunization with caprine arthritis-encephalitis virus surface glycoprotein.
复制标题
用山羊关节炎脑炎病毒表面糖蛋白免疫诱导的交叉反应中和抗体。
DOI：
10.1016/s0264-410x(99)00181-4
复制
发表时间：
2000
期刊：
影响因子：
5.5
通讯作者：
Cheevers,WP
中科院分区：
文献类型：
--
作者：
Kemp,RK;Knowles,DP;Perry,LL;McGuire,TC;Besser,TE;Cheevers,WP
Four Saanen goats were immunized with affinity purified gp135 surface glycoprotein (SU) of caprine arthritis–encephalitis virus isolate 79–63 (CAEV-63) and evaluated for homologous and crossreactive serum neutralizing antibodies. CAEV-63 neutralizing antibodies were detected in all goats after seven immunizations with SU in Quil A adjuvant. Sera from three goats neutralized an independent CAEV isolate (CAEV-Co). However, serum from one goat did not detectably neutralize heterologous CAEV-Co and inhibited CAEV-Co neutralization by another serum.
