Cancer morbidity in British military veterans included in chemical warfare agent experiments at Porton Down: cohort study.
Cancer morbidity in British military veterans included in chemical warfare agent experiments at Porton Down: cohort study.
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DOI：
10.1136/bmj.b655
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发表时间：
2009-03-24
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影响因子：
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通讯作者：
Venables KM
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文献类型：
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作者：
Carpenter LM;Linsell L;Brooks C;Keegan TJ;Langdon T;Doyle P;Maconochie NE;Fletcher T;Nieuwenhuijsen MJ;Beral V;Venables KM
目的 确定 1941 年至 1989 年间参加化学战剂测试的武装部队成员的癌症发病率。设计历史队列研究，对队列成员进行随访至 2004 年 12 月。数据来源：英国波顿唐政府研究机构档案、英国军事人员记录以及国家死亡和癌症记录。参与者 纳入死亡率队列研究的所有退伍军人，不包括那些已知在 1971 年 1 月 1 日英国癌症登记系统开始之前死亡或失访的退伍军人：参加测试的 17 013 名英国武装部队男性成员（Porton Down 退伍军人）和由 16 520 名未参加测试的男性组成的类似组（非 Porton Down 退伍军人）。主要结果衡量每组退伍军人的癌症发病率；比率，置信区间为 95%，并根据年龄组和日历周期进行调整。结果 Porton Down 退伍军人报告了 3457 例癌症，而非 Porton Down 退伍军人报告了 3380 例癌症。虽然两组的总体癌症发病率相同（比率为 1.00，95% 置信区间为 0.95 至 1.05），但波顿当退伍军人的不明恶性肿瘤（1.12、1.02 至 1.22）、原位肿瘤（1.45、1.06 至 2.00）以及行为不确定或未知的肿瘤（1.32、 1.01 至 1.73）。结论 Porton Down 退伍军人的总体癌症发病率与非 Porton Down 退伍军人没有什么不同。
Objective To determine cancer morbidity in members of the armed forces who took part in tests of chemical warfare agents from 1941 to 1989. Design Historical cohort study, with cohort members followed up to December 2004. Data source Archive of UK government research facility at Porton Down, UK military personnel records, and national death and cancer records. Participants All veterans included in the cohort study of mortality, excluding those known to have died or been lost to follow-up before 1 January 1971 when the UK cancer registration system commenced: 17 013 male members of the UK armed forces who took part in tests (Porton Down veterans) and a similar group of 16 520 men who did not (non-Porton Down veterans). Main outcome measures Cancer morbidity in each group of veterans; rate ratios, with 95% confidence intervals, adjusted for age group and calendar period. Results 3457 cancers were reported in the Porton Down veterans compared with 3380 cancers in the non-Porton Down veterans. While overall cancer morbidity was the same in both groups (rate ratio 1.00, 95% confidence interval 0.95 to 1.05), Porton Down veterans had higher rates of ill defined malignant neoplasms (1.12, 1.02 to 1.22), in situ neoplasms (1.45, 1.06 to 2.00), and those of uncertain or unknown behaviour (1.32, 1.01 to 1.73). Conclusion Overall cancer morbidity in Porton Down veterans was no different from that in non-Porton Down veterans.