Regulation of Hedgehog signaling by ubiquitination.
Regulation of Hedgehog signaling by ubiquitination.
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DOI：
10.1007/s11515-015-1343-5
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发表时间：
2015-06
期刊：
影响因子：
--
通讯作者：
Zheng X
中科院分区：
文献类型：
--
作者：
Hsia EY;Gui Y;Zheng X
Hedgehog (Hh) 信号通路在胚胎发育和成体干细胞功能中发挥着至关重要的作用。 Hh 信号活动的时间、持续时间和位置需要严格控制。 Hh信号转导异常会导致出生缺陷或恶性肿瘤。最近的数据表明，几个关键 Hh 通路组件的泛素化相关翻译后修饰是 Hh 通路调节的重要机制。在这里，我们回顾泛素化如何调节关键 Hh 信号成分的定位、稳定性和活性。
The Hedgehog (Hh) signaling pathway plays crucial roles both in embryonic development and in adult stem cell function. The timing, duration and location of Hh signaling activity need to be tightly controlled. Abnormalities of Hh signal transduction lead to birth defects or malignant tumors. Recent data point to ubiquitination-related posttranslational modifications of several key Hh pathway components as an important mechanism of regulation of the Hh pathway. Here we review how ubiquitination regulates the localization, stability and activity of the key Hh signaling components.