The effect of undernutrition on cholesterol atherosclerosis in the rabbit.
The effect of undernutrition on cholesterol atherosclerosis in the rabbit.
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DOI：
10.1084/jem.99.3.261
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发表时间：
1954-03
期刊：
影响因子：
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通讯作者：
DUFF GL
中科院分区：
文献类型：
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作者：
McMILLAN GC;WHITESIDE JH;DUFF GL
进行了实验，以确定是否营养不足，随之而来的体重减轻或未能增加体重抑制的发展或促进实验性胆固醇动脉粥样硬化的主动脉病变的兔消退。实验的进行是为了确定营养不良和营养充足的兔子在实验结束时是否会表现出不同程度的动脉粥样硬化。不同的实验测试了营养不良对无法正常增加体重的年轻生长动物的影响（实验1和2）;在喂食胆固醇之前和期间，（实验3）;在营养不良期间体重减轻的完全生长的成熟家兔中（实验4）;以及在开始热量限制之前已经完成一段时间的胆固醇喂养的兔子（实验5）。在每个实验中，观察到，如果两组兔子被喂食胆固醇，一组进行热量限制，而另一组接受足够的饮食，在实验结束时，在两组之间没有观察到主动脉粥样硬化的差异。此外，在家兔中未观察到营养不良对动脉粥样硬化病变消退的明显影响。与此同时，营养不良被发现促进高胆固醇血症的兔子喂胆固醇。讨论了这一结果的可能意义。
Experiments were done to determine whether undernutrition with consequent loss of weight or failure to gain weight inhibited the development or promoted the regression of the aortic lesions of experimental cholesterol atherosclerosis in the rabbit. The experiments were conducted in such a way as to determine whether undernourished and adequately nourished rabbits fed the same daily doses of cholesterol would manifest different degrees of atherosclerosis at the end of an experiment. Different experiments tested the effect of undernutrition in young, growing animals that failed to gain weight normally (Experiments 1 and 2); in young rabbits subjected to marked undernutrition both before and during cholesterol feeding (Experiment 3); in fully grown, mature rabbits that lost weight during undernutrition (Experiment 4); and in rabbits that had completed a period of cholesterol feeding before caloric restriction was begun (Experiment 5). In every experiment it was observed that, if two groups of rabbits were fed cholesterol, one group being subjected to caloric restriction while the other received an adequate diet, no difference in aortic atherosclerosis was observed between the two groups at the termination of the experiment. Furthermore, no obvious effect of undernutrition on the regression of atherosclerotic lesions was observed in the rabbit. At the same time, undernutrition was found to promote hypercholesterolemia in the rabbit fed cholesterol. The possible significance of this result was discussed.