The glomerular filtration rate in unrestrained rabbits determined by means of an implanted telemetrical device.
The glomerular filtration rate in unrestrained rabbits determined by means of an implanted telemetrical device.
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通过植入的遥测装置测定不受限制的兔子的肾小球滤过率。
DOI：
10.1111/j.1748-1716.1983.tb07195.x
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
J. Bojsen
中科院分区：
文献类型：
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作者：
S. Vadstrup;J. Bojsen
采用一种植入式无线电遥测装置，该装置由盖格-米<s:1>探测器、高压电源和调频发射机组成，包裹在重量为130 g的钠盐中，用于测量125i -碘甲酸酯单次静脉注射后在不受约束和不受干扰的家兔体内的消失率。在给药后10 ~ 60分钟内，血浆消失曲线呈单指数变化，消失速率常数（Ke）与125i -碘甲酸酯血浆消失曲线的“最终斜率”（kp） r=0.99密切相关。恒定输注清除技术同时测量的Ke与GFR之间也存在线性相关（r=0.98），该技术使用的是盖格-迈勒检测器无法检测到的指标（51Cr-EDTA）。125i -碘甲酸酯、51Cr-EDTA和菊粉的肾脏清除率之比，由于目前文献中没有数据，因此采用持续输注清除率技术在单独的一系列实验中测定。结果表明，GFR可以用遥测法测定，在正常家兔的一系列实验中，GFR平均为4.7 ml。最低为1。Kg-1（表达为菊粉清除率）。采用相同方法，戊巴比妥轻度麻醉家兔GFR平均值为3.5 ml。最低为1。公斤。
An implanted radio-telemetrical device, which consists of a Geiger-Müller detector, a high voltage supply and a FM transmitter, incapsulated in araldite (weight 130 g) was used to measure the body disappearance rate of 125I-iothalamate following a single i.v. bolus in unrestrained and undisturbed rabbits. The disappearance curve is practically monoexponential from 10 to 60 minutes after administration of the indicator and the disappearance rate constant (Ke) is closely correlated to the "final slope" of the plasma disappearance curve of 125I-iothalamate (kp) r=0.99). A linear correlation was also found between Ke and GFR measured simultaneously by constant infusion clearance technique, using an indicator not detected by the Geiger-Müller detector (51Cr-EDTA) (r=0.98). The ratios between the renal clearances of 125I-iothalamate, 51Cr-EDTA and inulin were determined by constant infusion clearance technique in a separate series of experiments since no data were available in the present literature. The results show that GFR can be determined by means of the telemetrical method and in a series of experiments in undisturbed rabbits GFR was found to be on average 4.7 ml . min-1 . kg-1 (expressed as inulin clearance). Using the same technique in lightly pentobarbital anesthetized rabbits GFR was on average 3.5 ml . min-1 . kg-1.