Gene expression profiling in the striatum of amphetamine-treated spontaneously hypertensive rats which showed amphetamine conditioned place preference and self-administration
Gene expression profiling in the striatum of amphetamine-treated spontaneously hypertensive rats which showed amphetamine conditioned place preference and self-administration
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DOI：
10.1007/s12272-014-0470-x
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发表时间：
2015-05-01
影响因子：
6.7
通讯作者：
Cheong, Jae Hoon
中科院分区：
文献类型：
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作者：
dela Pena, Ike;de la Pena, June Bryan;Cheong, Jae Hoon
注意力缺陷/多动障碍（ADHD）是儿童期最常见的神经行为障碍，通常用精神兴奋剂（例如，安非他明）。很少有人知道慢性安非他明使用或滥用的ADHD患者的神经和行为后果。在所有ADHD动物模型中，自发性高血压大鼠（SHR）是最有效且使用最广泛的。在这里，我们分析了安非他明预处理的SHR（5 mg/kg，腹腔注射7天[每日两次]）的纹状体转录组，这表明了对安非他明的条件性位置偏好和自我管理。微阵列分析显示55个基因的mRNA表达增加（>1.65倍增加），而17个基因下调（
Attention-deficit/hyperactivity disorder (ADHD), the most commonly diagnosed neurobehavioral disorder of childhood, is usually treated with psychostimulants (e.g., amphetamine). Little is known about the neuronal and behavioral consequences of chronic amphetamine use or abuse in individuals with ADHD. Of all ADHD animal models, the spontaneously hypertensive rat (SHR) is the most validated and widely used. Here, we analyzed striatal transcriptomes in amphetamine-pretreated SHRs (5 mg/kg, i.p. for 7 days [ twice daily]), which showed a conditioned place preference to and self-administration of amphetamine. Microarray analyses revealed increased mRNA expression of 55 genes (>1.65-fold increase), while 17 genes were downregulated (