Stress and consumption of alcohol in humans with a Type 1 family history of alcoholism in an experimental laboratory setting
Stress and consumption of alcohol in humans with a Type 1 family history of alcoholism in an experimental laboratory setting
复制标题
DOI：
10.1016/j.pbb.2011.05.028
复制
发表时间：
2011-10-01
影响因子：
3.6
通讯作者：
Soderpalm, Bo
中科院分区：
文献类型：
--
作者：
Gordh, Anna H. V. Soderpalm;Brkic, Sejla;Soderpalm, Bo
背景：本文研究有酗酒家族史的受试者压力与饮酒的相互作用。酒精摄入量增加的一个机制可能是压力改变了药物产生的主观效应。方法：58名健康志愿者，分为两组家族史阳性（FHP）和两组家族史阴性（FHN），参加两个实验阶段，其中一个阶段完成应激任务。然后，受试者被允许根据他们被随机分配的开始阶段，选择最多六种额外的乙醇或安慰剂饮料。结果：FHP受试者在应激后饮酒增加。结论：有可能压力和酒精都特别夸大了FHP个体的奖励感觉，从而增加了消费更多酒精的可能性。(C) 2011出版的爱思唯尔公司。
Background: This paper investigates how stress interacts with alcohol consumption in subjects with a family history of alcoholism. One mechanism for increases in alcohol intake may be that stress alters the subjective effects produced by the drug.Methods: 58 healthy volunteers, divided into two groups of family history positive (FHP) and two groups of family history negative (FHN) participated in two laboratory sessions, in which they performed in one out of two sessions a stress task. Then subjects were allowed to choose up to six additional drinks of ethanol or placebo depending on which session they were randomly assigned to start with.Results: It was found that FHP subjects increased their consumption of alcohol after stress.Conclusions: It is possible that both stress and alcohol specifically exaggerate the feelings of the reward in the FHP individuals in such way that it may increase the likelihood of consuming more alcohol. (C) 2011 Published by Elsevier Inc.