INTRATHECAL ADMINISTRATION OF CGRP IN THE RAT ATTENUATES A FACILITATION OF THE TAIL FLICK REFLEX INDUCED BY EITHER SUBSTANCE-P OR NOXIOUS CUTANEOUS STIMULATION
INTRATHECAL ADMINISTRATION OF CGRP IN THE RAT ATTENUATES A FACILITATION OF THE TAIL FLICK REFLEX INDUCED BY EITHER SUBSTANCE-P OR NOXIOUS CUTANEOUS STIMULATION
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DOI：
10.1016/0304-3940(89)90085-2
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发表时间：
1989-07-31
影响因子：
2.5
通讯作者：
HENRY, JL
中科院分区：
文献类型：
--
作者：
CRIDLAND, RA;HENRY, JL
清醒大鼠鞘内注射P物质可减少甩尾试验的反应时间。在麻醉大鼠中，对尾巴进行有害的热刺激（通过将尖端浸入55度的水中）。C)也降低RT；这种作用被P物质拮抗剂阻断。本研究探讨了降钙素基因相关肽（CGRP）对这两种范式中产生的RT减少的影响。CGRP （3.25 nmol, i.t.）预处理可分别减弱和消除P物质（3.25 nmol, i.t.）和皮肤刺激引起的RT下降。这些结果表明CGRP和P物质在甩尾反射的调节中有相互作用。
Intrathecal (i.t.) administration of substance P in the awake rat decreases reaction time (RT) in the tail flick test. In the anaesthetized rat, noxious thermal stimulation of the tail (by immersion of tip in water at 55.degree. C) also decreases RT; this effect is blocked by a substance P antagonist. The present study examines the effects of calcitonin gene-related peptide (CGRP) on the decrease in RT produced in these two paradigms. Pretreatment with CGRP (3.25 nmol, i.t.) attenuated and abolished the decreases in RT produced by substance P (3.25 nmol, i.t.) and by naxious cutaneous stimulation, respectively. These results indicate an interaction of CGRP and substance P in the regulation of the tail flick reflex.