Understanding the regulation of Group B Streptococcal virulence factors.
Understanding the regulation of Group B Streptococcal virulence factors.
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DOI：
10.2217/17460913.4.2.201
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发表时间：
2009-03
影响因子：
3.1
通讯作者：
Rajagopal L
中科院分区：
文献类型：
--
作者：
Rajagopal L
细菌感染仍然是对新生儿和成人健康的重大威胁。B族链球菌（GBS）是革兰氏阳性菌，是健康成人常见的无症状定植者。然而，这种机会微生物也可以破坏次优宿主防御，导致严重的侵入性疾病和组织损伤。越来越多的耐药性GBS的出现引起了人们对该疾病治疗的持续措施的更多关注。已经确定了许多对GBS毒力重要的因素。本文综述了一些特征性的毒力因子的功能，重点是GBS如何调节其表达。调节和信号分子是治疗细菌感染的有吸引力的药物靶标。因此，了解GBS的信号反应是必不可少的阐明GBS感染的发病机制和识别新的治疗药物。
Bacterial infections remain a significant threat to the health of newborns and adults. Group B Streptococci (GBS) are Gram-positive bacteria that are common asymptomatic colonizers of healthy adults. However, this opportunistic organism can also subvert suboptimal host defenses to cause severe invasive disease and tissue damage. The increasing emergence of antibiotic-resistant GBS raises more concerns for sustained measures in treatment of the disease. A number of factors that are important for virulence of GBS have been identified. This review summarizes the functions of some well-characterized virulence factors, with an emphasis on how GBS regulates their expression. Regulatory and signaling molecules are attractive drug targets in the treatment of bacterial infections. Consequently, understanding signaling responses of GBS is essential for elucidation of pathogenesis of GBS infection and for the identification of novel therapeutic agents.