Intrauterine Growth Restriction and the Sex Specific Programming of Leptin and Peroxisome Proliferator-Activated Receptor γ (PPARγ) mRNA Expression in Visceral Fat in the Lamb
Intrauterine Growth Restriction and the Sex Specific Programming of Leptin and Peroxisome Proliferator-Activated Receptor γ (PPARγ) mRNA Expression in Visceral Fat in the Lamb
复制标题
DOI：
10.1203/pdr.0b013e3181a7c121
复制
发表时间：
2009-07-01
影响因子：
3.6
通讯作者：
McMillen, I. Caroline
中科院分区：
文献类型：
--
作者：
Duffield, Jaime A.;Vuocolo, Tony;McMillen, I. Caroline
Being born small is associated with an increased risk of visceral obesity and insulin resistance in adult life. We have investigated the effect of IUGR on adipogenic and lipogenic gene expression in visceral fat in the lamb at 3 wk of age. Perirenal fat mass, but not adipocyte size was greater in females than males, independent of birth weight. Plasma insulin concentrations during the first 24 It after birth predicted the size of the adipocytes and expression of adiponectin in visceral adipose tissue in both males and females. In females, plasma nonesterified fatty acids (NEFA) concentrations during the first 24 h after birth were directly related to peroxisome proliferator-activated receptor gamma (PPAR gamma) mRNA expression in the perirenal fat depot at 3 wk of age. In the males, in contrast to the females, PPAR gamma and leptin expression in perirenal visceral fat were significantly lower in IUGR compared with control lambs. Thus, the early nutritional environment programs adipocyte growth and gene expression in visceral adipose tissue. The differential effect of sex and IUGR on PPAR gamma and leptin expression in visceral fat may be important in the subsequent development of visceral obesity and the insulin resistant phenotype in later life. (Pediatr Res 66: 59-65, 2009)
