Research Trends and Hotspots Analysis Related to the Effects of Xenobiotics on Glucose Metabolism in Male Testes
Research Trends and Hotspots Analysis Related to the Effects of Xenobiotics on Glucose Metabolism in Male Testes
复制标题
异生素对男性睾丸葡萄糖代谢影响的研究趋势和热点分析
DOI：
10.3390/ijerph15081590
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发表时间：
2018-08-01
影响因子：
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通讯作者：
Wang, Chunhong
中科院分区：
文献类型：
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作者：
Fan, Yongsheng;Yu, Guangxia;Wang, Chunhong
本研究旨在整合和分析现有研究，探讨外源性物质对男性睾丸糖代谢影响的相关研究趋势和热点。所有文章均从PubMed数据库中检索，起始日期至2017年6月10日。使用CiteSpace软件（版本5.1.R8 SE）进行共词聚类分析。本研究共纳入165篇合格出版物。1949-1959年，只发表了两篇文章。1960年以后，文章数量稳步增加。这些文章发表在97种期刊上，特别是印度实验生物学杂志（11篇，6.7%）。大多数作者（87.0%）只发表一篇文章。只有少数几个已建立的研究团队，主要来自美国，在这一领域持续工作。已研究的主要外源性物质是药物和常见的环境污染物，棉酚、镉、邻苯二甲酸二正丁酯和α-氯乙醇。热点关键词为支持细胞、乳酸脱氢酶、6-磷酸脱氢酶、氧化应激、葡萄糖代谢。随着时间的推移，研究的重点也发生了变化。这是第一个文献计量学研究外源性物质和葡萄糖代谢的男性睾丸。研究结果表明，环境污染物已成为一个巨大的关注，相关的研究应该加强。
This study aimed to integrate and analyze the existing studies and to explore research trends and hotspots related to the effects of xenobiotics on glucose metabolism in male testes. All articles were retrieved from the PubMed database, from an inception date up to 10 June 2017. CiteSpace software (version 5.1.R8 SE) was used for the co-word cluster analysis. A total of 165 eligible publications were included in this study. In 1949-1959, only two articles were published. After 1960, the number of articles increased steadily. These articles were published in 97 journals, in particular, in the Indian Journal of Experimental Biology (11 articles, 6.7%). Most of the authors (87.0%) only published one article. Only a few established research teams, mostly from the USA, worked consistently in this field. The main xenobiotics that had been studied were medicine and common environmental pollutants, e.g., gossypol, cadmium, di-n-butyl phthalate, and alpha-chlorohydrin. The hotspot keywords were Sertoli cell, lactate dehydrogenase, 6-phosphate dehydrogenase, oxidative stress, and glucose metabolism. The focus of research had been changed overtime. This is the first bibliometric study between xenobiotics and glucose metabolism in the male testes. The findings suggest that environmental pollutants have become a huge concern, and related research should be strengthened.