Potential drug-drug interactions among hospitalized patients in a developing country
Potential drug-drug interactions among hospitalized patients in a developing country
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DOI：
10.22088/cjim.8.4.282
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发表时间：
2017-01-01
影响因子：
1.4
通讯作者：
Ghanbari, Golshan
中科院分区：
文献类型：
--
作者：
Mousavi, Sarah;Ghanbari, Golshan
背景：药物相互作用（DDI）通常会导致可预防的药物不良事件和健康损害。特别是在医院，这可能是一个重要因素，因为多种药物治疗很常见。本研究的目的是确定潜在的DDI在内科病房在伊朗大学hospital.Methods的频率和水平：一个横断面研究进行了审查图表的448名住院患者在内科病房的教学医院，从2014年11月至2015年5月。采用Lexicomp药物相互作用软件和Micromedex Drug-Reax系统筛选潜在的DDI。按严重程度对识别出的DDI进行分类。应用逻辑回归来确定潜在DDI的特定风险因素的比值比，例如，结果：患者平均年龄61岁，平均住院时间9 d，平均每例患者使用药物9种。在386例患者中检测到潜在的相互作用。最常见的相互作用类型为C型（78.6%）、中度（60.9%）和延迟发作（56.5%）。潜在DDI的发生与7种或7种以上处方药物显著相关（OR：0.048，95%CI：0.02-0.12，p
Background: Drug-drug interactions (DDIs) may often lead to preventable adverse drug events and health damage. Particularly in hospitals, this might be an important factor as multiple drug therapies are common. The objective of this study was to identify the frequency and levels of potential DDIs in internal medicine wards in an Iranian university hospital.Methods: A cross-sectional study was conducted by reviewing charts of 448 hospitalized patients in internal medicine wards of a teaching hospital, from November 2014 to May 2015. "Lexicomp drug interaction software" and Micromedex Drug-Reax system were used for screening the potential DDIs. The identified DDIs were categorized by level of severity. Logistic regression was applied to determine the odds ratio for specific risk factors of potential DDIs e.g., age, gender, hospital stay and number of medications.Results: The mean age of patients was 61 years, the length of hospital stay for patients was 9 days and the number of drugs per patient was 9. Potential interactions were detected in 386 patients. The most common types of interactions were type C (78.6%), moderate (60.9%) and delayed onset (56.5%). There was a significant association of the occurrence of potential DDIs with seven or more numbers of prescribed medications (OR: 0.048, 95% CI: 0.02-0.12, p