Small-fiber neuropathy: answering the burning questions.
Small-fiber neuropathy: answering the burning questions.
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DOI：
10.1126/sageke.2006.6.pe7
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发表时间：
2006-03-08
期刊：
影响因子：
--
通讯作者：
Oaklander, Anne Louise
中科院分区：
文献类型：
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作者：
Fink, Ezekiel;Oaklander, Anne Louise
小纤维神经病是一种周围神经疾病，最常见于中老年人，他们的脚会出现灼痛。虽然它可以由代谢紊乱引起，如糖尿病，慢性感染（如人类免疫缺陷病毒），遗传异常，各种药物的毒性，以及自身免疫性疾病，但原因往往仍然是一个谜，因为神经损伤的标准电生理测试不能检测小纤维功能。测试和诊断小纤维神经病的能力不足阻碍了患者的护理和研究，但新工具提供了希望。很少，小纤维功能障碍的根本原因是确定和疾病修饰治疗可以制定。更常见的是，小纤维神经病的治疗涉及神经性疼痛的对症治疗。
Small-fiber neuropathy is a peripheral nerve disease that most commonly presents in middle-aged and older people, who develop burning pain in their feet. Although it can be caused by disorders of metabolism such as diabetes, chronic infections (such as with human immunodeficiency virus), genetic abnormalities, toxicity from various drugs, and autoimmune diseases, the cause often remains a mystery because standard electrophysiologic tests for nerve injury do not detect small-fiber function. Inadequate ability to test for and diagnose small-fiber neuropathies has impeded patient care and research, but new tools offer promise. Infrequently, the underlying cause of small-fiber dysfunction is identified and disease-modifying therapy can be instituted. More commonly, the treatments for small-fiber neuropathy involve symptomatic treatment of neuropathic pain.