Meta-analysis of five genome-wide linkage studies for body mass index reveals significant evidence for linkage to chromosome 8p
Meta-analysis of five genome-wide linkage studies for body mass index reveals significant evidence for linkage to chromosome 8p
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DOI：
10.1038/sj.ijo.0802817
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发表时间：
2005-04-01
影响因子：
4.9
通讯作者：
Teare, MD
中科院分区：
文献类型：
--
作者：
Johnson, L;Luke, A;Teare, MD
目的：为了进行荟萃分析的全基因组连锁扫描使用身体质量指数（BMI），以确定遗传位点predisposingtoobesity.DATA：共有13个已发表的基因组扫描肥胖使用BMI作为其主要终点。这13组中的5组同意提供荟萃分析所需的详细扫描结果。方法：采用GSMA（genome scans meta-analysis）方法对5项研究的结果进行分析。结果：5项研究的结果显示，BMI的数量表型与8 p有显著的相关性（P < 0.0005）。
OBJECTIVE: To perform a meta-analysis of genome-wide linkage scans using body mass index (BMI) to identify genetic loci predisposing to obesity.DATA: A total of 13 published genome scans on obesity have used BMI as their primary end point. Five of these 13 groups agreed to provide detailed results from their scans that were required for a meta-analysis. Collectively, these five studies included a total of 2814 individuals from 505 families.METHODS: The results of the five studies were analysed using the GSMA (genome scans meta-analysis) method.RESULTS: The analysis revealed significant evidence for linkage of the quantitative phenotype BMI to 8p (P < 0.0005).