C-myc oncogene family expression in glioblastoma and survival
C-myc oncogene family expression in glioblastoma and survival
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DOI：
10.1016/s0090-3019(98)00028-7
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发表时间：
1999-05-01
影响因子：
--
通讯作者：
Kretzschmar, HA
中科院分区：
文献类型：
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作者：
Herms, JW;von Loewenich, FD;Kretzschmar, HA
背景技术在胶质瘤中，c-myc原癌基因表达被发现与恶性肿瘤的分级相关，在I级和II级肿瘤中低表达，在III级和IV级肿瘤中高表达。我们的目的是发现 myc 表达在胶质母细胞瘤中是否具有预后意义。 方法 使用原位杂交技术，在 46 例成人患者的幕上胶质母细胞瘤中研究了 c-myc、N-myc 和 L-myc 原癌基因以及 max 基因的表达。 结果 78% 的肿瘤表达 c-myc mRNA，84% max mRNA，57% N-myc mRNA 和 57% L-myc mRNA。分别分析60岁以上患者和60岁以下患者的术后生存率，因为发现年龄增长与术后生存时间呈负相关（p = 0.004）。在两个年龄组中，肿瘤分别表达 c-myc、N-myc 或 L-myc 的患者与肿瘤不表现出这种特征的患者之间，术后生存率没有显着差异。然而，在 60 岁以上年龄组中，肿瘤表达 max 的程度等于或小于 c-myc 的患者和肿瘤表达 max 的程度大于 c-myc 或既不表达 max 又不表达 c-myc 的患者之间的术后生存率存在差异。结论老年患者中胶质母细胞瘤的生物学行为可能取决于 c-myc 蛋白和相互作用蛋白的相对含量，而不是绝对含量。 (C) 1999 年，爱思唯尔科学公司。
BACKGROUND In gliomas, c-myc protooncogene expression has been found to correlate with the grade of malignancy, with low expression in Grade I and II and high expression in Grade III and IV tumors. We aimed to discover if myc expression is of prognostic significance in glioblastomas.METHODS Expression of the c-myc, N-myc, and L-myc protooncogenes and of the max gene was investigated in 46 supratentorial glioblastomas from adult patients using in situ hybridization.RESULTS Seventy-eight percent of the tumors expressed c-myc m-RNA, 84% max m-RNA, 57% N-myc m-RNA, and 57% L-myc m-RNA. The postoperative survival of patients over 60 years of age and that of patients under 60 years of age were analyzed separately, since advancing age was found to be negatively correlated with the duration of postoperative survival (p = 0.004). There was no significant difference in postoperative survival in either age group between patients whose tumors expressed either c-myc, N-myc, or L-myc, respectively, and those whose tumors did not exhibit this characteristic. A difference in postoperative survival, however, was found in the over 60-year age group between patients whose tumors expressed max to an equal or lesser extent than c-myc and those whose tumors expressed max to a greater extent than c-myc or neither max nor c-myc.CONCLUSION The biologic behavior of glioblastomas in older patients may depend on the relative, but not on the absolute content of the c-myc protein and interacting proteins. (C) 1999 by Elsevier Science Inc.