Multiplexed imaging in cancer diagnosis: applications and future advances.
Multiplexed imaging in cancer diagnosis: applications and future advances.
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DOI：
10.1016/s1470-2045(10)70009-7
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发表时间：
2010-06
期刊：
影响因子：
51.1
通讯作者：
Kawamoto, Satomi
中科院分区：
文献类型：
--
作者：
Kobayashi, Hisataka;Longmire, Michelle R.;Ogawa, Mikako;Choyke, Peter L.;Kawamoto, Satomi
长期以来，肿瘤学的目标一直是发展具有足够特异性和敏感性的成像技术，以便能够早期、准确地检测癌症并对治疗产生反应。各种放射技术已被用于疾病复发的诊断和监测，影像学已经彻底改变了肿瘤学。然而，尽管技术的广泛使用，目前可用的成像方法促进早期发现、精确表征和准确定位恶性疾病的能力仍有待提高。同时使用两种或多种技术，造影剂，信号方法，或耦合剂和组织特性来实现所谓的多路成像是一种很有前途的方法。在这篇综述中，我们提供了当前和新兴的多路复用成像技术的广泛概述。
The development of imaging technologies that have sufficient specificity and sensitivity to enable early, accurate detection of cancer and response to therapy has long been a goal in oncology. Various radiological techniques have been used for diagnosis and surveillance of disease recurrence and imaging has revolutionised oncology. However, despite the widespread use of technologies, the ability of currently available imaging methods to facilitate early detection, precise characterisation, and accurate localisation of maligant disease could be improved. The simultaneous use of two or more techniques, contrast reagents, signalling methods, or the coupling of agent and tissue properties to achieve so-called multiplexed imaging is a promising approach. In this review, we provide a broad overview of current and emerging multiplexed, imaging technologies.