Use of Medications for Treating Anxiety or Depression among Testicular Cancer Survivors: A Multi-Institutional Study.
Use of Medications for Treating Anxiety or Depression among Testicular Cancer Survivors: A Multi-Institutional Study.
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在睾丸癌幸存者中使用药物治疗焦虑或抑郁症：一项多机构研究。
DOI：
10.1158/1055-9965.epi-20-1762
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发表时间：
2021-06
期刊：
影响因子：
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通讯作者：
Travis LB
中科院分区：
文献类型：
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作者：
ArdeshirRouhaniFard S;Dinh PC;Monahan PO;Fossa SD;Huddart R;Fung C;Song Y;Feldman DR;Hamilton RJ;Vaughn DJ;Martin NE;Kollmannsberger C;Einhorn L;Kroenke K;Travis LB
本研究探讨了社会人口学因素，顺铂相关的不良健康结局（AHO），以及与睾丸癌幸存者（TCS）焦虑和/或抑郁药物使用相关的累积发病率负担（CBMPt）评分。共有1，802名TCS完成了≥12个月的顺铂化疗，之前完成了关于社会人口统计学特征和顺铂相关AHO（听力损害、耳鸣、周围感觉神经病变（PSN）、肾脏疾病）的问卷调查。CBMPt评分包括顺铂相关AHO的数量和严重程度。多变量logistic回归模型评估了个体AHO和CBMPt与焦虑和/或抑郁药物使用的关系。共有151名TCS（8.4%）使用药物治疗焦虑和/或抑郁。511例（28.4%）受试者未报告顺铂相关AHO，而622例（34.5%）、334例（18.5%）、287例（15.9%）和48例（2.7%）的CBMPt评分分别为极低、低、中和高。在多变量模型中，较高的CBMPt评分与焦虑和/或抑郁的药物使用显著相关（P<0.0001）。此外，耳鸣（P=0.0009）、PSN（P=0.02）和有健康保险（P=0.05）与这些药物的使用量增加显著相关;而就业（P=0.0005）和剧烈的体力活动（P=0.01）与使用量减少显著相关。具有较高CBMPt评分的TCS使用药物治疗焦虑和/或抑郁的概率较高，相反，那些有工作和身体活动的人倾向于减少使用这些药物。医疗保健提供者应鼓励TCS增加体力活动，以改善身心健康。康复方案应评估与工作有关的技能，并提供职业发展咨询/培训。
This study examined sociodemographic factors, cisplatin-related adverse health outcomes (AHOs), and cumulative burden of morbidity (CBMPt) scores associated with medication use for anxiety and/or depression in testicular cancer survivors (TCS). A total of 1,802 TCS who completed cisplatin-based chemotherapy ≥12 months previously completed questionnaires regarding sociodemographic features and cisplatin-related AHOs (hearing impairment, tinnitus, peripheral sensory neuropathy (PSN), kidney disease). A CBMPt score encompassed the number and severity of cisplatin-related AHOs. Multivariable logistic regression models assessed the relationship of individual AHOs and CBMPt with medication use for anxiety and/or depression. A total of 151 TCS (8.4%) used medications for anxiety and/or depression. No cisplatin-related AHO were reported by 511 (28.4%) participants, whereas 622 (34.5%), 334 (18.5%), 287 (15.9%), and 48 (2.7%), respectively had very low, low, medium, and high CBMPt scores. In the multivariable model, higher CBMPt scores were significantly associated with medication use for anxiety and/or depression (P<0.0001). Additionally, tinnitus (P=0.0009), PSN (P=0.02), and having health insurance (P=0.05) were significantly associated with greater use of these medications; whereas being employed (P=0.0005) and vigorous physical activity (P=0.01) were significantly associated with diminished use. TCS with higher CBMPt scores had a higher probability of using medications for anxiety and/or depression and conversely, those who were employed and physically active tended to have reduced use of these medications. Healthcare providers should encourage TCS to increase physical activity to improve both physical and mental health. Rehabilitation programs should assess work-related skills and provide career development counseling/training.