The implications of cell‐free DNAs derived from tumor viruses as biomarkers of associated cancers
The implications of cell‐free DNAs derived from tumor viruses as biomarkers of associated cancers
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DOI：
10.1002/jmv.27903
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发表时间：
2022-06
影响因子：
12.7
通讯作者：
Yiwei Wang;Yanling Li;Xinyu Liang;Shuyu Xin;Li Yang;Pengfei Cao;Mingjuan Jiang;Yujie Xin;Senmiao Zhang;Yang Yang-Yang;Jianhong Lu
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文献类型：
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作者：
Yiwei Wang;Yanling Li;Xinyu Liang;Shuyu Xin;Li Yang;Pengfei Cao;Mingjuan Jiang;Yujie Xin;Senmiao Zhang;Yang Yang-Yang;Jianhong Lu
根据世界卫生组织（WHO）的估计，癌症仍然是导致死亡的主要原因，肿瘤病毒和人类癌症之间的密切联系已经被证明了近六十年。无细胞DNA（cfDNA）作为一种流行的癌症生物标志物，因其动态，即时和非侵入性的优势而引起了极大的关注。cfDNA主要从凋亡细胞和从癌细胞释放的外来体释放，包括被病毒感染的那些。虽然cfDNA在外周血中以低浓度存在，但它们可以高灵敏度地反映肿瘤负荷。考虑到肿瘤病毒与相关癌症的相关性，来源于病毒的cfDNA可以作为早期筛查、诊断和治疗监测的良好生物标志物。在这篇综述中，我们总结了用于检测来自不同体液的cfDNA的方法和新开发的分析技术，并讨论了来自不同肿瘤病毒的cfDNA在病毒相关癌症的检测和治疗监测中的意义。更好地了解肿瘤病毒来源的cfDNA可能有助于制定新的抗肿瘤策略，以减少归因于病毒的癌症负担。
Cancer is still ranked as a leading cause of death according to estimates from the World Health Organization (WHO) and the strong link between tumor viruses and human cancers have been proved for almost six decades. Cell‐free DNA (cfDNA) has drawn enormous attention for its dynamic, instant, and noninvasive advantages as one popular type of cancer biomarker. cfDNAs are mainly released from apoptotic cells and exosomes released from cancer cells, including those infected with viruses. Although cfDNAs are present at low concentrations in peripheral blood, they can reflect tumor load with high sensitivity. Considering the relevance of the tumor viruses to the associated cancers, cfDNAs derived from viruses may serve as good biomarkers for the early screening, diagnosis, and treatment monitoring. In this review, we summarize the methods and newly developed analytic techniques for the detection of cfDNAs from different body fluids, and discuss the implications of cfDNAs derived from different tumor viruses in the detection and treatment monitoring of virus‐associated cancers. A better understanding of cfDNAs derived from tumor viruses may help formulate novel antitumoral strategies to decrease the burden of cancers that attributed to viruses.