Magnetic resonance imaging (MRI)and electroencephalographic (EEG) findings in a cohort of normal children with newly diagnosed seizures
Magnetic resonance imaging (MRI)and electroencephalographic (EEG) findings in a cohort of normal children with newly diagnosed seizures
复制标题
DOI：
10.1177/08830738060210061901
复制
发表时间：
2006-06-01
影响因子：
1.9
通讯作者：
Austin, Joan K.
中科院分区：
文献类型：
--
作者：
Doescher, Jason S.;deGrauw, Ton J.;Austin, Joan K.
在对新发癫痫发作儿童的初步评估中，脑电图（EEG）应作为标准检查，磁共振成像（MRI）应作为可选检查的建议受到质疑。本研究的目的是（1）描述EEG和MRI异常的频率，（2）探索MRI和EEG结果之间的关系，以确定其在评估新发癫痫发作儿童中的相关性，这些儿童在其他方面发育正常。作为一项正在进行的对新发癫痫儿童的前瞻性研究的一部分，我们研究了181名儿童（90名女孩和91名男孩）。儿童在首次确认癫痫发作后3个月内进入研究。使用卡方检验探讨EEG和MRI异常之间的关联。32.6%（n = 59）的样本中发现了异常MRI结果。EEG和MRI结果在37%（n = 67）的正常或异常分类方面一致。然而，在脑电图正常的50名儿童中，有21名（42%）被发现有异常的MRI。我们发现在我们的正常儿童样本中，成像异常的频率出乎意料地高，尽管这些发现的意义尚不清楚。对这些患者的随访将有助于我们解释异常的重要性。尽管我们的样本相对较小，然而，我们的研究结果表明，正常的脑电图并不能可靠地预测正常的MRI在儿童首次癫痫发作。
In the initial assessment of children with new-onset seizures, the suggestion that electroencephalography (EEG) should be standard and that magnetic resonance imaging (MRI) should be optional has been questioned. The purposes of this study were to (1) describe the frequency of EEG and MRI abnormalities and (2) explore relationships between MRI and EEG findings to determine their relevance in the assessment of children with new-onset seizures who are otherwise developing normally. As part of an ongoing, prospective study of children with new-onset seizures, we studied 181 children (90 girls and 91 boys). Children were entered into the study within 3 months of their first-recognized seizure. The association between EEG and MRI abnormalities was explored using a chi-square test. Abnormal MRI findings were found in 32.6% (n = 59) of the sample. The EEG and MRI results agreed with respect to classification into normal or abnormal in 37% (n = 67). Of the 50 children with a normal EEG, however, 21 (42%) were found to have an abnormal MRI. We found an unexpectedly high frequency of imaging abnormalities in our sample of otherwise normal children, although the significance of these findings is not clear. Follow-up of these patients will help us interpret the importance of the abnormalities. Despite our relatively small sample, however, our findings indicate that a normal EEG does not reliably predict a normal MRI in children with first seizures.