The effect of sodium benzoate on ammonia toxicity in rats.
The effect of sodium benzoate on ammonia toxicity in rats.
复制标题
苯甲酸钠对大鼠氨毒性的影响。
DOI：
10.1016/0006-291x(86)90290-1
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发表时间：
1986
影响因子：
3.1
通讯作者：
Tremblay,GC
中科院分区：
文献类型：
--
作者：
Maswoswe,SM;Cyr,DM;Griffith,AD;Tremblay,GC
在9.5 mmol/kg体重时，苯甲酸钠急剧增加随后用氨激发的大鼠的死亡率。禁食动物对苯甲酸盐氨毒性增强的敏感性低于喂食动物。在2.5 mmol/kg体重时，观察到苯甲酸盐可保护禁食动物免受氨毒性。氨消失，尿素形成，和马尿酸合成在离体肝细胞悬浮液的测量表明，苯甲酸酯通过抑制尿素循环增强氨毒性。
At 9.5 mmoles/kg body weight, sodium benzoate sharply increased mortality in rats subsequently challenged with ammonia. Fasted animals were less sensitive to potentiation of ammonia toxicity by benzoate than were fed animals. At 2.5 mmoles/kg body weight, benzoate was observed to protect fasted animals against ammonia toxicity. Measurements of ammonia disappearance, urea formation, and hippurate synthesis in suspensions of isolated hepatocytes indicate that benzoate potentiates ammonia toxicity by inhibiting the urea cycle.