The Hedgehog signalling pathway regulates autophagy.
The Hedgehog signalling pathway regulates autophagy.
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DOI：
10.1038/ncomms2212
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发表时间：
2012
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
--
作者：
自噬是一种高度保守的降解过程，在饥饿期间去除受损或不必要的蛋白质和细胞器，并重新包装细胞质内容物。自噬在胚胎发育等生理过程中是必不可少的，但自噬如何受到典型发育途径的调控尚不清楚。在这里，我们表明，刺猬信号通路抑制自噬体的合成，无论是在基础和自噬诱导的条件。这种机制在哺乳动物细胞和果蝇中是保守的，并且分别需要正向转录因子Gli 2和Ci。此外，我们发现Hedgehog通路的激活降低了PERK水平，伴随着翻译起始因子真核起始因子2α磷酸化的降低，这表明该通路的新靶点，并提供了Hedgehog信号传导和自噬之间的可能联系。自噬是控制蛋白质和细胞器周转的细胞过程。Jimenez-Sanchez及其同事在培养的哺乳动物细胞和果蝇幼虫中证明，自噬是由Hedgehoc信号转导调节的，这是一种对早期胚胎发育很重要的途径。
Autophagy is a highly conserved degradative process that removes damaged or unnecessary proteins and organelles, and recycles cytoplasmic contents during starvation. Autophagy is essential in physiological processes such as embryonic development but how autophagy is regulated by canonical developmental pathways is unclear. Here we show that the Hedgehog signalling pathway inhibits autophagosome synthesis, both in basal and in autophagy-induced conditions. This mechanism is conserved in mammalian cells and in Drosophila, and requires the orthologous transcription factors Gli2 and Ci, respectively. Furthermore, we identify that activation of the Hedgehog pathway reduces PERK levels, concomitant with a decrease in phosphorylation of the translation initiation factor eukaryotic initiation factor 2α, suggesting a novel target of this pathway and providing a possible link between Hedgehog signalling and autophagy. Autophagy is a cellular process that controls protein and organelle turnover. Jimenez-Sanchez and colleagues demonstrate in cultured mammalian cells and in fruit fly larvae that autophagy is regulated by Hedgehoc signalling, a pathway that is important for early embryonic development.
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DOI：
10.1083/jcb.152.4.657
发表时间：
2001-02-19
期刊：
The Journal of cell biology
影响因子：
--
作者：
Mizushima N;Yamamoto A;Hatano M;Kobayashi Y;Kabeya Y;Suzuki K;Tokuhisa T;Ohsumi Y;Yoshimori T
通讯作者：
Yoshimori T
影响因子：
2.7
作者：
Mich, John K.;Blaser, Heiko;Thomas, Natalie A.;Firestone, Ari J.;Yelon, Deborah;Raz, Erez;Chen, James K.
通讯作者：
Chen, James K.
影响因子：
64.8
作者：
Fimia, Gian Maria;Stoykova, Anastassia;Cecconi, Francesco
通讯作者：
Cecconi, Francesco
影响因子：
3.7
作者：
Lipinski, Robert J.;Gipp, Jerry J.;Bushman, Wade
通讯作者：
Bushman, Wade
影响因子：
56.9
作者：
Berman, DM;Karhadkar, SS;Beachy, PA
通讯作者：
Beachy, PA