Important predictor of mortality in patients with end-stage liver disease.
Important predictor of mortality in patients with end-stage liver disease.
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DOI：
10.3350/cmh.2013.19.2.105
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发表时间：
2013-06
影响因子：
8.9
通讯作者：
Lee HW
中科院分区：
文献类型：
--
作者：
Kim HJ;Lee HW
预后是对任何疾病进行基线评估的重要组成部分。为了预测终末期肝病的预后，人们提出了许多预测模型。近三十年来，Child-Pugh评分一直是评估终末期肝病患者肝硬变预后的参考指标。尽管有一些局限性，但最近的大型系统综述表明，Child-Pugh评分仍然是可靠的预测因子，其组成部分(胆红素、白蛋白和凝血酶原时间)紧随其后的是Child-Pugh评分。最近，终末期肝病模型(MELD)评分作为Child-Pugh评分的“现代”替代品出现。MELD评分在准确预测肝病严重程度和有效评估死亡风险方面发挥了重要作用。由于MELD评分的几个弱点，新的修正的MELD评分(MELD-Na，Delta MELD)已经被开发和验证。本文综述了目前对终末期肝病预后因素的认识，重点介绍了Child-Pugh评分和MELD评分的作用。
Prognosis is an essential part of the baseline assessment of any disease. For predicting prognosis of end-stage liver disease, many prognostic models were proposed. Child-Pugh score has been the reference for assessing the prognosis of cirrhosis for about three decades in end-stage liver disease. Despite of several limitations, recent large systematic review showed that Child-Pugh score was still robust predictors and it's components (bilirubin, albumin and prothrombin time) were followed by Child-Pugh score. Recently, Model for end-stage liver disease (MELD) score emerged as a "modern" alternative to Child-Pugh score. The MELD score has been an important role to accurately predict the severity of liver disease and effectively assess the risk of mortality. Due to several weakness of MELD score, new modified MELD scores (MELD-Na, Delta MELD) have been developed and validated. This review summarizes the current knowledge about the prognostic factors in end-stage liver disease, focusing on the role of Child-Pugh and MELD score.