Pathogenesis and transmission of swine-origin 2009 A(H1N1) influenza virus in ferrets.
Pathogenesis and transmission of swine-origin 2009 A(H1N1) influenza virus in ferrets.
复制标题
DOI：
10.1126/science.1177127
复制
发表时间：
2009-07-24
期刊：
影响因子：
--
通讯作者：
Fouchier RA
中科院分区：
文献类型：
--
作者：
Munster VJ;de Wit E;van den Brand JM;Herfst S;Schrauwen EJ;Bestebroer TM;van de Vijver D;Boucher CA;Koopmans M;Rimmelzwaan GF;Kuiken T;Osterhaus AD;Fouchier RA
2009年初出现在人类身上的猪源甲型H1N1流感病毒引起了人们对大流行发展的担忧。在雪貂致病和传播模型中，发现2009年甲型H1N1流感病毒比季节性甲型H1N1流感病毒更具致病性，更广泛的病毒复制发生在呼吸道。季节性甲型H1N1流感病毒的复制仅限于雪貂的鼻腔，但2009年甲型H1N1流感病毒也在气管、支气管和细支气管处复制。与季节性病毒相比，2009年甲型H1N1流感病毒从上呼吸道脱落的病毒更多，通过气雾剂或呼吸道飞沫传播的效率相同。这些数据表明，2009年甲型H1N1流感病毒有能力在人群中持续存在，可能会产生更严重的临床后果。
The swine-origin A(H1N1) influenza virus that has emerged in humans in early 2009 has raised concerns about pandemic developments. In a ferret pathogenesis and transmission model, the 2009 A(H1N1) influenza virus was found to be more pathogenic than a seasonal A(H1N1) virus, with more extensive virus replication occurring in the respiratory tract. Replication of seasonal A(H1N1) virus was confined to the nasal cavity of ferrets, but the 2009 A(H1N1) influenza virus also replicated in the trachea, bronchi, and bronchioles. Virus shedding was more abundant from the upper respiratory tract for 2009 A(H1N1) influenza virus as compared with seasonal virus, and transmission via aerosol or respiratory droplets was equally efficient. These data suggest that the 2009 A(H1N1) influenza virus has the ability to persist in the human population, potentially with more severe clinical consequences.