Intra-tumoral tertiary lymphoid structures are associated with a low risk of early recurrence of hepatocellular carcinoma
Intra-tumoral tertiary lymphoid structures are associated with a low risk of early recurrence of hepatocellular carcinoma
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DOI：
10.1016/j.jhep.2018.09.003
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发表时间：
2019-01-01
影响因子：
25.7
通讯作者：
Sautes-Fridman, Catherine
中科院分区：
文献类型：
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作者：
Calderaro, Julien;Petitprez, Florent;Sautes-Fridman, Catherine
背景和目标：三级淋巴样结构（TLS）为产生抗肿瘤细胞和体液免疫应答提供了局部和关键的微环境。TLS与迄今为止研究的大多数实体瘤的临床结局改善相关。然而，它们在肝细胞癌（HCC）中的作用是有争议的，因为它们最近被证明是促进恶性肝细胞祖细胞在non-tumoralliver.Methods的生长：我们的目的是确定，通过病理学检查，肿瘤内和非肿瘤的TLSs的预后意义在一系列的273例HCC患者在亨利蒙多大学医院手术切除治疗。结果：47%的肿瘤组织病理学检查发现TLSs，其中26%的肿瘤组织可见淋巴样聚集体，16%的肿瘤组织可见初级滤泡，5%的肿瘤组织可见次级滤泡。单变量和多变量分析显示，肿瘤内TLS与较低的早期复发风险显著相关（
Background & Aims: Tertiary lymphoid structures (TLSs) provide a local and critical microenvironment for generating anti-tumor cellular and humoral immune responses. TLSs are associated with improved clinical outcomes in most solid tumors investigated to date. However, their role in hepatocellular carcinoma (HCC) is debated, as they have recently been shown to promote the growth of malignant hepatocyte progenitors in the non-tumoral liver.Methods: We aimed to determine, by pathological review, the prognostic significance of both intra-tumoral and non-tumoral TLSs in a series of 273 patients with HCC treated by surgical resection in Henri Mondor University Hospital. Findings were further validated by gene expression profiling using a public data set (LCI cohort).Results: TLSs were identified in 47% of the tumors, by pathological review, with lymphoid aggregates, primary and secondary follicles in 26%, 16% and 5% of the cases, respectively. Univariate and multivariate analyses showed that intra-tumoral TLSs significantly correlated with a lower risk of early relapse (