Test-Retest Reliability of Thermal Temporal Summation Using an Individualized Protocol
Test-Retest Reliability of Thermal Temporal Summation Using an Individualized Protocol
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DOI：
10.1016/j.jpain.2012.10.010
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发表时间：
2013-01-01
期刊：
影响因子：
4
通讯作者：
Mackey, Sean
中科院分区：
文献类型：
--
作者：
Kong, Jiang-Ti;Johnson, Kevin A.;Mackey, Sean
暂时性总和(TS)指的是重复的伤害性刺激增加了对疼痛的感知。这是一种与缠绕有关的行为关联，即反复C纤维刺激的脊髓易化。为了在临床疼痛研究中使用TS，重要的是在广泛的个体中描述TS的特征并建立其重测可靠性。在固定参数协议的基础上，我们开发了一个单独调整的协议来广泛捕获热产生的TS。然后，我们检验了TS的日内(试验间隔2到30分钟)和日间(试验间隔7天)的重测信度。我们在21名参与者中的19名中产生了类似TS的效果。在两天的所有试验(组内相关性[ICC][A，10]=.97，95%可信水平[CL]=.94.99)和初始试验之间的强相关性(ICC[A，1]=.83，95%CL=.58.93)中观察到强相关性。重复测量混合效应模型显示没有显著的日内差异，仅有很小的日内差异(满分为100分)。最后，Bland-Altman的分析表明，在观察到的分数范围内，TS是可靠的。在没有干预的情况下，热产生的IS在白天和白天之间通常是稳定的。观点：我们的研究引入了一种新的策略，在高比例的个体中产生热TS。这项研究证实了热刺激的重测可靠性，支持将其作为中枢伤害性易化的一致行为相关性。(C)2013年度美国疼痛协会
Temporal summation (TS) refers to the increased perception of pain with repetitive noxious stimuli. It is a behavioral correlate of wind-up, the spinal facilitation of recurring C-fiber stimulation. In order to utilize TS in clinical pain research, it is important to characterize TS in a wide range of individuals and to establish its test-retest reliability. Building on a fixed-parameter protocol, we developed an individually adjusted protocol to broadly capture thermally generated TS. We then examined the test-retest reliability of TS within-day (intertrial intervals ranging from 2 to 30 minutes) and between-days (intersession interval of 7 days). We generated TS-like effects in 19 of the 21 participants. Strong correlations were observed across all trials over both days (intraclass correlation [ICC] [A, 10] = .97, 95% confidence level [CL] = .94.99) and across the initial trials between days (ICC [A, 1] = .83, 95% CL = .58.93). Repeated measures mixed-effects modeling demonstrated no significant within-day variation and only a small (5 out of 100 points) between-day variation. Finally, a Bland-Altman analysis suggested that TS is reliable across the range of observed scores. Without intervention, thermally-generated IS is generally stable within day and between days.Perspective: Our study introduces a new strategy to generate thermal TS in a high proportion of individuals. This study confirms the test-retest reliability of thermal TS, supporting its use as a consistent behavioral correlate of central nociceptive facilitation. (C) 2013 by the American Pain Society