Non-steroidal Anti-inflammatory Drugs Are a Risk Factor for Cisplatin-induced Nephrotoxicity: A Meta-analysis of Retrospective Studies
Non-steroidal Anti-inflammatory Drugs Are a Risk Factor for Cisplatin-induced Nephrotoxicity: A Meta-analysis of Retrospective Studies
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DOI：
10.21873/anticanres.14128
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发表时间：
2020-03-01
影响因子：
2
通讯作者：
Kobayashi, Masaki
中科院分区：
文献类型：
--
作者：
Okamoto, Keisuke;Saito, Yoshitaka;Kobayashi, Masaki
背景/目的：既往研究表明，非甾体类抗炎药（NSAID）是顺铂所致肾毒性（CIN）的危险因素。在这里，通过荟萃分析对这些先前研究的结果进行了全面评估。材料与方法：在数据库检索以选择合格的研究后，使用森林图进行荟萃分析，然后评估异质性和发表偏倚以及亚组分析。结果：7项研究被提取为候选者。所有研究均为回顾性研究，并将NSAID对CIN的影响作为次要终点进行评价。根据荟萃分析，总优势比为1.88（95%置信区间= 1.44 - 2.45）。此外，未观察到高度异质性和发表偏倚。化疗评价期的亚组分析显示，通过NSAID联合给药，CIN在第一个疗程组中倾向于增强（仅在1个疗程中进行评价），在总疗程组中显著增强（在1个或多个疗程中进行评价）。结论：NSAID联合用药可能是CIN的危险因素。
Background/Aim: Previous reports have demonstrated that non-steroidal anti-inflammatory drugs (NSAIDs) are a risk factor for cisplatin-induced nephrotoxicity (CIN). Here, the results of these previous studies were comprehensively assessed via a meta-analysis. Materials and Methods: After a database search to select eligible studies, a meta-analysis was performed using a forest plot, followed by an assessment of the heterogeneity and publication bias and a subgroup analysis. Results: Seven studies were extracted as candidates. All were retrospective studies and evaluated the effect of NSAIDs on CIN as a secondary endpoint. According to the meta-analysis, total odds ratio was 1.88 (95% confidence interval=1.44-2.45). Further, high heterogeneity and publication bias were not observed. A subgroup analysis of the chemotherapy evaluation period revealed that CIN tended to be enhanced in the first course group (evaluation in only 1 course) and was significantly enhanced in the total course group (evaluation in 1 or more courses) by NSAIDs co-administration. Conclusion: NSAIDs co-administration could be a risk factor for CIN.