The role of the laterodorsal tegmental nucleus of the rat in experimental seizures.
The role of the laterodorsal tegmental nucleus of the rat in experimental seizures.
复制标题
大鼠背侧被盖核在实验性癫痫发作中的作用。
DOI：
10.1016/0306-4522(91)90415-k
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发表时间：
1991
期刊：
影响因子：
3.3
通讯作者：
Gray,BC
中科院分区：
文献类型：
--
作者：
Miller,JW;Bardgett,ME;Gray,BC
本研究确定了离散微量注射GABA激动剂的自发行为和癫痫发作引起的静脉注射戊四氮，荷包牡丹碱或士的宁，在大鼠的脑桥中脑被盖的胆碱能核的影响。在背外侧被盖核注射GABA A激动剂哌啶-4-磺酸和GABA B激动剂（−）巴氯芬，产生了剂量依赖性的行为觉醒抑制，并降低了荷包牡丹碱和戊四氮诱导的肌阵挛和阵挛发作阈值，但不降低强直性发作阈值。对任何类型的士的宁癫痫发作均无显著影响。注射周围的脑干结构，包括脚桥被盖核，对自发行为的影响不大，并没有显着改变的阈值戊四氮诱导的seizure.We先前已经证明，注射GABA激动剂在中央内侧intralaminar核的丘脑有类似的行为和癫痫发作的影响。由于中央内侧核接受被盖背外侧核的重要直接胆碱能投射，这两个核团形成一个离散的上行系统，调节癫痫发作阈值。
This study determined the effects of discrete microinjections of GABA agonists in the cholinergic nuclei of the pontomesencephalic tegmentum on spontaneous behavior and seizures induced by intravenous pentylenetetrazol, bicuculline or strychnine, in the rat. Injections of both the GABAAagonist piperidine-4-sulfonic acid and the GABABagonist (−)baclofen in the laterodorsal tegmental nucleus produced a dose-dependent suppression of behavioral arousal and a reduction in the threshold of myoclonic and clonic but not tonic seizures induced by bicuculline and pentylenetetrazol. There were no significant effects on any type of strychnine seizure. Injections in the surrounding brainstem structures, including the pedunculopontine tegmental nucleus, had little effect on spontaneous behavior and did not significantly alter the thresholds of pentylenetetrazol-induced seizures.We have previously demonstrated that injections of GABA agonists in the central medial intralaminar nucleus of the thalamus have similar effects on behavior and seizures. Since the central medial nucleus receives important direct cholinergic projections from the laterodorsal tegmental nucleus, these two nuclei form a discrete ascending system which regulates seizure threshold.