Daily exercise attenuates the sympathetic component of the arterial baroreflex control of heart rate
Daily exercise attenuates the sympathetic component of the arterial baroreflex control of heart rate
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DOI：
10.1152/ajpheart.1997.273.6.h2613
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发表时间：
1997-12-01
影响因子：
4.8
通讯作者：
DiCarlo, SE
中科院分区：
文献类型：
--
作者：
Collins, HL;DiCarlo, SE
在16只雌性Long Evans大鼠[8只安静（SED）和8只DSR]上研究了每日自发跑步（DSR）对动脉压力反射控制心率（HR）的交感（SC）和副交感成分的影响。在8-9周的SED对照或DSR后，用动脉和静脉导管对动物进行长期器械化。DSR导致心脏重量/体重比增加（2.71 +/- 0.11 vs. 3.09 +/- 0.09 g/kg）和静息心动过缓（378 +/- 6 vs. 330 +/- 5次/min）。在以下三种实验条件下，在苯肾上腺素和硝普钠的斜坡输注期间检查动脉压力反射功能：1）对照，2）β（1）-肾上腺素能受体阻断（β（1）-X）后，和3）毒蕈碱-胆碱能受体阻断（M-X）后。比较SED和DSR大鼠的动脉压力反射功能参数。在对照条件下，DSR减弱了范围（182 +/- 15 vs. 124 +/- 18次/分钟）、最大HR（464 +/- 9 vs. 394 +/- 15次/分钟）和最大增益（G（max）; 5.57 +/- 0.42 vs. 3.2 +/- 0.45次/分钟（-1）.mmHg（-1））。同样，M-X后，DSR减弱了范围（84 +/- 5 vs. 62 +/- 8次/分）、最大HR（449 +/- 11 vs. 412 +/- 11次/分）和G（max）（2.73 +/- 0.37 vs. 1.57 +/- 0.32次/分（-1）.mmHg（-1））。相比之下，β（1）-X后，DSR未改变范围（61 +/- 13 vs. 70 +/- 7次/分）、最大HR（326 +/- 9 vs. 313 +/- 7次/分）或G（max）（3.04 +/- 0.54 vs. 3.75 +/- 0.52次/分（-1）.mmHg（-1））。结果表明，DSR减弱动脉压力感受性反射控制的HR通过减少SC。
The influence of daily spontaneous running (DSR) on the sympathetic (SC) and parasympathetic components of the arterial baroreflex control of heart rate (HR) was examined in 16 female Long Evans rats [8 sedentary (SED) and 8 DSR]. After 8-9 wk of SED control or DSR, animals were chronically instrumented with arterial and venous catheters. DSR resulted in an increased heart weight-to-body weight ratio (2.71 +/- 0.11 vs. 3.09 +/- 0.09 g/kg) and a resting bradycardia (378 +/- 6 vs. 330 +/- 5 beats/min). Arterial baroreflex function was examined during ramp infusions of phenylephrine and sodium nitroprusside under the following three experimental conditions: 1) control, 2) after beta(1)-adrenergic receptor blockade (beta(1)-X), and 3) after muscarinic-cholinergic receptor blockade (M-X). Arterial baroreflex function parameters were compared between SED and DSR rats. In the control condition, DSR attenuated the range (182 +/- 15 vs. 124 +/- 18 beats/min), maximum HR (464 +/- 9 vs. 394 +/- 15 beats/min), and maximal gain (G(max); 5.57 +/- 0.42 vs. 3.2 +/- 0.45 beats min(-1).mmHg(-1)). Similarly, after M-X, DSR attenuated the range (84 +/- 5 vs. 62 +/- 8 beats/min), maximum HR (449 +/- 11 vs. 412 +/- 11 beats/min), and G(max) (2.73 +/- 0.37 vs. 1.57 +/- 0.32 beats min(-1).mmHg(-1)). In contrast, after beta(1)-X, DSR did not alter the range (61 +/- 13 vs. 70 +/- 7 beats/min), maximum HR (326 +/- 9 vs. 313 +/- 7 beats/min), or G(max) (3.04 +/- 0.54 vs. 3.75 +/- 0.52 beats min(-1).mmHg(-1)). Results demonstrate that DSR attenuated the arterial baroreflex control of HR by reducing the SC.