Clinical course of pyruvate kinase deficiency in Abyssinian and Somali cats
Clinical course of pyruvate kinase deficiency in Abyssinian and Somali cats
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DOI：
10.1016/j.jfms.2007.09.006
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发表时间：
2008-04-01
影响因子：
1.7
通讯作者：
Fumi, Christine
中科院分区：
文献类型：
--
作者：
Kohn, Barbara;Fumi, Christine
这项研究的目的是检查患有丙酮酸激酶(PK)缺乏的阿比西尼亚和索马里猫的临床症状、实验室参数和病程。对25只PK缺陷猫的临床病程进行了0.8-11.3年(中位数4.3)的随访。据主人说，11只猫(年龄0.8-7.8岁，中位数4.4岁)没有出现体征。在14只猫(年龄0.1-5岁，中位数1.7岁)中，主人注意到昏昏欲睡(10只)、腹泻(7只)、粘膜苍白(6只)、食欲不振(6只)、皮毛质量差(6只)、体重减轻(4只)、黄疸(4只)和食欲不振(2只)。在确诊之前，16只猫至少被用于繁殖一次。实验室异常包括贫血(70%)、聚集网织红细胞计数增加(94%)、高球蛋白血症(80%)、高胆红素血症(53%)和肝酶升高(47%)。在25只受影响的猫中，有6只死亡(4只)或被安乐死(2只)，年龄从1.3岁到11.3岁(中位数4.1岁)，推测是因为缺乏PK。这些发现强调，PK缺乏表现出发病年龄和体征严重程度的差异。由于缺乏PK的猫可能是无症状的，所以强烈建议在繁育之前进行PK缺乏的测试。(C)2007年ESFM和AAFP。爱思唯尔有限公司出版。保留所有权利。
The objective of this study was to examine clinical signs, laboratory parameters, and course of disease in Abyssinian and Somali cats with pyruvate kinase (PK) deficiency. The clinical course of 25 PK-deficient cats was followed over a time period of 0.8-11.3 years (median 4.3). Eleven cats (age 0.8-7.8 years, median 4.4) did not show signs according to the owners. In 14 cats (age 0.1-5 years, median 1.7) the owners noted lethargy (10), diarrhoea (seven), pale mucous membranes (six), inappetence (six), poor coat quality (six), weight loss (four), icterus (four), and pica (two). Sixteen cats had been used for breeding at least once before diagnosis. Laboratory abnormalities included anaemia (70%), increased aggregated reticulocyte counts (94%), hyperglobulinaemia (80%), hyperbilirubinaemia (53%), and increased liver enzymes (47%). Six of 25 affected cats died (four) or were euthanased (two) at ages ranging from 1.3 to 11.3 years (median 4.1) presumably because of PK-deficiency. These findings emphasise that PK deficiency shows variation in age of onset and severity of signs. As PK-deficient cats can be asymptomatic testing for PK deficiency before breeding is strongly recommended. (c) 2007 ESFM and AAFP. Published by Elsevier Ltd. All rights reserved.