Physiological-Model-Constrained Noninvasive Reconstruction of Volumetric Myocardial Transmembrane Potentials
Physiological-Model-Constrained Noninvasive Reconstruction of Volumetric Myocardial Transmembrane Potentials
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DOI：
10.1109/tbme.2009.2024531
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发表时间：
2010-02-01
影响因子：
4.6
通讯作者：
Shi, Pengcheng
中科院分区：
文献类型：
--
作者：
Wang, Linwei;Zhang, Heye;Shi, Pengcheng
个体化心电活动的无创成像可以指导和提高心律失常的预防性诊断和治疗。与体表电位（BSP）记录和心脏表面重建的电生理信息相比，容量心肌跨膜电位（TMP）动力学在显示心律失常细节和心肌内致心律失常底物方面具有更大的临床意义。本文提出了一个生理模型约束的统计框架，从无创BSP记录中重建三维心肌内的体积TMP动力学。通过心脏电生理系统的建模纳入了容量TMP活性的一般知识，并用于约束TMP重建。考虑到模型和数据的不确定性，该生理系统被重新表述为随机状态空间表示，并开发了非线性数据同化来从个人BSP数据估计容量心肌TMP动态。评估了该框架对实际模型和数据误差的鲁棒性。在计算幻像上对右束分支阻滞进行心外膜电位重建与经典正则化方法的比较。此外，对局部局部活动的模拟实验和对心肌梗死后的初步真实数据研究表明，该框架在重建局部心律失常细节和识别心肌内致心律失常底物方面具有潜力。
Personalized noninvasive imaging of subject-specific cardiac electrical activity can guide and improve preventive diagnosis and treatment of cardiac arrhythmia. Compared to body surface potential (BSP) recordings and electrophysiological information reconstructed on heart surfaces, volumetric myocardial transmembrane potential (TMP) dynamics is of greater clinical importance in exhibiting arrhythmic details and arrythmogenic substrates inside the myocardium. This paper presents a physiological-model-constrained statistical framework to reconstruct volumetric TMP dynamics inside the 3-D myocardium from noninvasive BSP recordings. General knowledge of volumetric TMP activity is incorporated through the modeling of cardiac electrophysiological system, and is used to constrain TMP reconstruction. This physiological system is reformulated into a stochastic state-space representation to take into account model and data uncertainties, and nonlinear data assimilation is developed to estimate volumetric myocardial TMP dynamics from personal BSP data. Robustness of the presented framework to practical model and data errors is evaluated. Comparison of epicardial potential reconstructions-with classical regularization-based approaches is performed on computational phantom regarding right bundle branch blocks. Further, phantom experiments on intramural focal activities and an initial real-data study on postmyocardial infarction demonstrate the potential of the framework in reconstructing local arrhythmic details and identifying arrhythmogenic substrates inside the myocardium.