Schizophrenia as a complex trait - Evidence from a meta-analysis of twin studies
Schizophrenia as a complex trait - Evidence from a meta-analysis of twin studies
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DOI：
10.1001/archpsyc.60.12.1187
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发表时间：
2003-12-01
影响因子：
--
通讯作者：
Neale, MC
中科院分区：
文献类型：
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作者：
Sullivan, PF;Kendler, KS;Neale, MC
背景：有许多关于精神分裂症的双胞胎研究发表。虽然这些研究之前已经被回顾过，但据我们所知，没有回顾提供了基因和环境对精神分裂症易感性的影响的定量总结估计，这也解释了所使用的不同确定策略。目的：从合并的双胞胎数据中计算遗传力、共同和个体特定环境影响的元分析估计。数据来源：我们使用结构化文献检索来确定所有已发表的关于精神分裂症的双胞胎研究，包括MEDLINE、论文和图书搜索。研究选择：在确定的14项研究中，12项符合系统确定的最低纳入标准。数据综合：通过使用多组双胞胎模型，我们发现了大量加性遗传效应的证据，精神分裂症倾向的遗传率点估计为81%（95%置信区间，73%-90%）。值得注意的是，这些研究中有一致的证据表明，共同或共同的环境影响对精神分裂症的倾向-联合估计，11%（95%置信区间，3%-19%）。结论：尽管有证据表明研究之间存在异质性，但这些来自12项已发表的双胞胎精神分裂症研究的荟萃分析结果与精神分裂症是一种由遗传和环境病因影响导致的复杂特征的观点一致。这些结果提供了广泛的信息，因为它们没有提供关于这些病因影响的具体身份的信息，但它们确实提供了一个统一的经验基础的组成部分，支持寻找潜在的遗传和常见的环境病因的合理性。
Context: There are many published twin studies of schizophrenia. Although these studies have been reviewed previously, to our knowledge, no review has provided quantitative summary estimates of the impact of genes and environment on liability to schizophrenia that also accounted for the different ascertainment strategies used.Objective: To calculate meta-analytic estimates of heritability in liability and shared and individual-specific environmental effects from the pooled twin data.Data Sources: We used a structured literature search to identify all published twin studies of schizophrenia, including MEDLINE, dissertation, and books-m-print searches.Study Selection: Of the 14 identified studies, 12 met the minimal inclusion criteria of systematic ascertainment.Data Synthesis: By using a multigroup twin model, we found evidence for substantial additive genetic effects the point estimate of heritability in liability to schizophrenia was 81% (95% confidence interval, 73%-90%). Notably, there was consistent evidence across these studies for common or shared environmental influences on liability to schizophrenia-joint estimate, 11% (95% confidence interval, 3%-19%).Conclusions: Despite evidence of heterogeneity across studies, these meta-analytic results from 12 published twin studies of schizophrenia are consistent with a view of schizophrenia as a complex trait that results from genetic and environmental etiological influences. These results are broadly informative in that they provide no information about the specific identity of these etiological influences, but they do provide a component of a unifying empirical basis supporting the rationality of searches for underlying genetic and common environmental etiological factors.