Brugia pahangi: quantitative analysis of infection in several inbred rat strains.
Brugia pahangi: quantitative analysis of infection in several inbred rat strains.
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彭亨布鲁格虫：几种近交系大鼠品系感染的定量分析。
作者：
R. Bell;L. Adams;S. Coleman;D. Negrão;T. Klei
我们报告了一个全面的研究，在8个不同的近交系的雄性和雌性大鼠的巴氏丝虫的感染性。任何近交系大鼠品系的单一感染将产生变成微丝蚴血症、具有隐匿性感染或清除原发感染的大鼠。属于任何类别的比例由该菌株的基本敏感性水平决定。通畅率（血液微丝蚴+）范围为24%（AO大鼠）至73%（WKA大鼠）。微丝蚴在循环中的时间与微丝蚴负担直接相关，大鼠携带低于50 mf/ml的血液的时间为11.8周± 12.2周; 50-499 mf/ml为37.6 ± 14.8周，500+ mf/ml为63.3 ± 34.2周。乳鼠对感染具有抵抗力（0例患者），断奶鼠的抵抗力介于乳鼠和成年鼠之间。雌性大鼠对感染具有高度抵抗力。大约一半的无微丝蚴血症大鼠有隐匿性感染。很大比例的显性感染涉及睾丸或睾丸炎。在最敏感的大鼠品系中，超过95%的L3或发育中的L4寄生虫在28天内被杀死。在前6个月的过程中，雄性与雌性的比例显着下降，表明雄性蠕虫的寿命较短。将大鼠感染性/通畅性模式的特征与在人群中获得的公认模式进行比较。我们的结论是，大鼠提供了一个有价值的和未充分利用的模型丝虫感染的实验分析。
We report a comprehensive study of the infectivity of Brugia pahangi in male and female rats of eight different inbred strains. A single infection of any inbred rat strain will produce rats that become microfilaremic, have occult infection, or clear the primary infection. The proportion belonging to any category is determined by the basic susceptibility level of that strain. Patency rates (blood microfilaria+) ranged from 24% (AO rats) to 73% (WKA rats). The period for which microfilaria were in the circulation was directly related to microfilarial burden, with rats carrying less than 50 mf/ml of blood patent for 11.8 weeks +/- 12.2; for 50-499 mf/ml it was 37.6 +/- 14.8 and for 500+ mf/ml it was 63.3 +/- 34.2 weeks. Suckling rats were resistant to infection (0 patent) and weanlings were intermediate in resistance between suckling and adult rats. Female rats were highly resistant to infection. Approximately half of amicrofilaremic rats have occult infections. A high proportion of patent infections involve the testes or testicular lymphatics. In the most susceptible rat strains, more than 95% of the administered L3 or developing L4 parasites were killed within 28 days. During the course of the first 6 months, the ratio of males to females fell significantly, suggesting a shorter life span in male worms. The features of the infectivity/patency patterns in rats are compared with recognized patterns obtaining in human populations. We conclude that rats provide a valuable and underutilized model for the experimental analysis of filarial infections.
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选择性饲养狗，以将肢体水肿与微丝丝血症作为布鲁氏菌感染的临床表现分开。
DOI：
10.4269/ajtmh.1990.43.489
发表时间：
1990
期刊：
The American journal of tropical medicine and hygiene
影响因子：
--
作者：
Miller,S;Snowden,K;Schreuer,D;Hammerberg,B
通讯作者：
Hammerberg,B
班克罗夫特丝虫病的社区诊断。
DOI：
10.1016/0035-9203(93)90277-w
发表时间：
1993
影响因子：
2.2
作者：
Faris,R;Ramzy,RM;Gad,AM;Weil,GJ;Buck,AA
通讯作者：
Buck,AA
DOI：
--
发表时间：
1989
期刊：
The American journal of pathology
影响因子：
--
作者：
Hines,SA;Crandall,RB;Crandall,CA;Thompson,JP
通讯作者：
Thompson,JP
淋巴结细胞释放的组胺和肿瘤坏死因子升高与感染彭亨丝虫的狗肢体水肿形成的遗传倾向之间的关系。
DOI：
10.4269/ajtmh.1998.58.695
发表时间：
1998
期刊：
The American journal of tropical medicine and hygiene
影响因子：
--
作者：
Orton,S;Weinstock,D;Hammerberg,B
通讯作者：
Hammerberg,B
彭亨布鲁格虫：感染持续时间和寄生虫负荷对沙鼠（Meriones unguiculatus）淋巴病变严重程度、肉芽肿性过敏和免疫反应的影响。
影响因子：
2.1
作者：
Klei,TR;McVay,CS;Dennis,VA;Coleman,SU;Enright,FM;Casey,HW
通讯作者：
Casey,HW