Metal-Free [2 2 2] Cycloaddition of Ynamide-Nitriles with Ynamides: A Highly Regio- and Chemoselective Synthesis of delta-Carboline Derivatives.
Metal-Free [2 2 2] Cycloaddition of Ynamide-Nitriles with Ynamides: A Highly Regio- and Chemoselective Synthesis of delta-Carboline Derivatives.
复制标题
无金属 [2 2 2] 酰胺-腈与酰胺的环加成：δ-咔啉衍生物的高度区域和化学选择性合成。
DOI：
10.1021/acs.joc.8b02112
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发表时间：
2018
影响因子：
3.6
通讯作者：
Tang Yu
中科院分区：
文献类型：
--
作者：
Wen Hao;Cao Wei;Liu Yu;Wang Liang;Chen Ping;Tang Yu
公开了官能化的炔酰胺-腈与炔酰胺的无金属形式[2 + 2 + 2]环加成，其在TfOH的介导下提供了高效获得多取代的δ-咔啉衍生物。该策略具有高度区域选择性和化学选择性，除了底物范围（56 个示例）外，还表现出温和的条件、高产率和效率（1 分钟内）。
A metal-free formal [2 + 2 + 2] cycloaddition of functionalized ynamide–nitriles with ynamides is disclosed which offers highly efficient access to polysubstituted δ-carboline derivatives under the mediation of TfOH. This strategy is highly regioselective and chemoselective and displays mild conditions, high yields, and efficiency (within 1 min) in addition to substrates scopes (56 examples).