Humanized Monoclonal Antibody That Passively Protects Mice against Systemic and Intranasal Ricin Toxin Challenge.
Humanized Monoclonal Antibody That Passively Protects Mice against Systemic and Intranasal Ricin Toxin Challenge.
复制标题
被动保护小鼠免受全身和鼻内蓖麻毒素挑战的人源化单克隆抗体。
DOI：
10.1128/cvi.00088-16
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Mantis,NicholasJ
中科院分区：
文献类型：
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作者：
VanSlyke,Greta;Sully,ErinK;Bohorova,Natasha;Bohorov,Ognian;Kim,Do;Pauly,MichaelH;Whaley,KevinJ;Zeitlin,Larry;Mantis,NicholasJ
PB10是针对蓖麻毒素酶亚基上的免疫显性表位的鼠单克隆抗体。在这里，我们的特点是一个完全人源化版本的PB10 IgG 1（hPB10），并证明它具有potentiin vitroandin体内毒素中和活性。我们还报告了当通过注射和吸入递送时，保护小鼠免受10倍于50%致死剂量的蓖麻毒素的hPB 10所需的最低血清浓度。
PB10 is a murine monoclonal antibody against an immunodominant epitope on ricin toxin's enzymatic subunit. Here, we characterize a fully humanized version of PB10 IgG1 (hPB10) and demonstrate that it has potentin vitroandin vivotoxin-neutralizing activities. We also report the minimum serum concentrations of hPB10 required to protect mice against 10 times the 50% lethal dose of ricin when delivered by injection and inhalation.