Pathenogenetic activation of mouse oocytes following avertin anaesthesia.
Pathenogenetic activation of mouse oocytes following avertin anaesthesia.
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阿弗丁麻醉后小鼠卵母细胞的致病激活。
DOI：
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发表时间：
1975
期刊：
影响因子：
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通讯作者：
M. Kaufman
中科院分区：
文献类型：
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作者：
M. Kaufman
阿维菌素麻醉诱导小鼠卵子成为激活孤雌生殖。当女性在排卵后6-5，9和13小时麻醉时，观察到激活的发生率增加，达到最大值45.8%。在自发排卵组中，大约12.5%的卵子排卵，或27.3%的卵子激活引起蜕膜反应，并在组织学上证实了植入胚胎的存在。这些研究结果表明，一种新的和简单的方法，诱导植入后孤雌发育的小鼠，并强调需要考虑到可能的后果麻醉在排卵后早期。
Avertin anaesthesia induced mouse eggs to become activated parthenogenetically. An increasing incidence of activation was observed when females were anaesthetized 6-5, 9 and 13 h after ovulation, reaching a maximum of 45.8 percent. In a spontaneously ovulating group approximately 12.5 percent of all the eggs ovulated, or 27.3 percent of all the eggs activated evoked a decidual response, and the presence of implanting embryos was confirmed histologically. These findings demonstrate a new and simple method of inducing post-implantation parthenogenetic development in the mouse, and stress the necessity of taking into account the possible consequences of anaesthesia in the early post-ovulatory period.