Synthesis of Polyfunctional Aromatic Ring Systems (Phloroglucide Analogs) under Microwave Irradiation
Synthesis of Polyfunctional Aromatic Ring Systems (Phloroglucide Analogs) under Microwave Irradiation
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微波辐照下多官能芳环体系（间苯葡萄糖苷类似物）的合成
DOI：
10.1002/hlca.200390192
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
G. Hakimelahi
中科院分区：
文献类型：
--
作者：
A. Khalafi‐Nezhad;M. Rad;G. Hakimelahi
描述了在微波辐射下有效且快速地合成间苯三酚类似物的方法。 4-卤代-2,6-双（羟甲基）苯酚 1a,b 与其他取代苯酚在 ZnCl2 存在下进行固相缩合反应，以比经典溶液相合成高得多的产率提供目标分子，并使我们能够制备具有通过现有方法难以获得的敏感官能团的新型间苯三酚类似物。
An efficient and rapid synthesis of phloroglucide analogs under microwave irradiation is described. The solid-phase condensation reaction of the 4-halo-2,6-bis(hydroxymethyl)phenols 1a,b with other substituted phenols in the presence of ZnCl2 afforded the target molecules in much higher yields than by classical solution-phase synthesis and allowed us to prepare new phloroglucide analogs possessing sensitive functional groups difficult to access by established means.