Reproducibility of changes in behaviour and fMRI activation associated with sleep deprivation in a working memory task
Reproducibility of changes in behaviour and fMRI activation associated with sleep deprivation in a working memory task
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DOI：
10.1093/sleep/30.1.61
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发表时间：
2007-01-01
期刊：
影响因子：
5.6
通讯作者：
Chee, Michael W. L.
中科院分区：
文献类型：
--
作者：
Lim, Julian;Choo, Wei-Chieh;Chee, Michael W. L.
研究目的：虽然睡眠剥夺的脆弱性的个体间差异的稳定性已被证明是行为，这些差异的神经基础尚未被发现。在这项研究中，我们评估了重复性的功能磁共振成像激活和性能的工作记忆任务之前和之后的24小时的睡眠剥夺（SID）。设计：所有志愿者进行了2次会议（对功能磁共振成像扫描）在休息清醒（RW）和SID后。参会人员：19名健康的右撇子受试者（平均年龄= 21.37 +/- 1.54岁）测量和结果：在先前涉及工作记忆功能的额顶叶网络中，大脑激活在各个阶段之间高度相关。SID后这种激活的下降幅度保留在双侧顶叶区域。在几个行为指标的调查，最强大的标记SID的脆弱性是在个体内的反应时间的变化。这被证明是稳定的，随着时间的推移和相关的下降，左顶叶激活从RW SID在两个实验sessions.Conclusions：由于其可重复性，顶叶激活的调制可能提供了一个很好的生理标记的脆弱性SID。
Study Objectives: Although the stability of inter-individual differences in vulnerability to sleep deprivation has been shown behaviourally, the neural basis for these differences has yet to be uncovered. In this study, we assessed the reproducibility of fMRI activation and performance on a working memory task before and after 24 hours of sleep deprivation (SID).Design: All volunteers underwent 2 sessions (pairs of fMRI scans) at rested wakefulness (RW) and after SID. Participants: 19 healthy, right-handed subjects (mean age = 21.37 +/- 1.54 years)Measurements and Results: Brain activation was highly correlated across sessions in a frontoparietal network previously implicated in working memory function. The magnitude of decline in this activation after SID was preserved in bilateral parietal regions. Among several behavioural metrics investigated, the most robust marker of vulnerability to SID was the change in the intra-individual variability of reaction times. This was shown to be both stable over time and correlated with the drop in left parietal activation from RW to SID in both experimental sessions.Conclusions: Because of its reproducibility, the modulation of parietal activation may provide a good physiological marker of vulnerability to SID.