The molecular biology of mammalian SIRT proteins - SIRT2 in cell cycle regulation
The molecular biology of mammalian SIRT proteins - SIRT2 in cell cycle regulation
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DOI：
10.4161/cc.6.9.4219
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发表时间：
2007-05-01
期刊：
影响因子：
4.3
通讯作者：
Oshimura, Mitsuo
中科院分区：
文献类型：
--
作者：
Inoue, Toshiaki;Hiratsuka, Masaharu;Oshimura, Mitsuo
Sir 2是一种依赖于NAD（+）的蛋白质脱乙酰酶，可以延长从酵母到苍蝇等多种物种的寿命。哺乳动物有7个Sir 2的同源物，SIRT 1 -7，它们影响衰老和代谢，是药物干预的潜在靶点。我们鉴定了SIRT 2，它优先使微管蛋白和组蛋白H4脱乙酰，由于其表观遗传畸变，SIRT 2在神经胶质瘤中是一种下调蛋白。本文讨论了SIRT 2在有丝分裂检查点功能中的作用，并表明它可能作为抗癌药物的潜在靶点。
Sir2, an NAD(+)-dependent protein deacetylase, extends the lifespan in diverse species from yeast to flies. Mammals have seven homologs of Sir2, SIRT1-7, which affect aging and metabolism and which are potential targets for pharmacologic intervention. We identified SIRT2, which preferentially deacetylates tubulin and histone H4, as a downregulated protein in gliomas due to its epigenetic aberration. We herein discuss the role of SIRT2 in the mitotic checkpoint function and show that it may be as a potential target of anti-cancer drugs.