Matrix Mediated Viral Gene Delivery: A Review.
Matrix Mediated Viral Gene Delivery: A Review.
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DOI：
10.1021/acs.bioconjchem.8b00853
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发表时间：
2019-02
影响因子：
4.7
通讯作者：
D. Steinhauff;H. Ghandehari
中科院分区：
文献类型：
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作者：
D. Steinhauff;H. Ghandehari
聚合物基质固有地保护病毒载体免受预先存在的免疫条件的影响，限制传播到靶点以外的位置，并能够维持载体的释放。发展基于颗粒物的载体的先进方法已经导致了病毒载体的更好的封装。聚合物递送系统有助于增加细胞转导、反应释放机制、细胞渗透和细胞信号转导。合成聚合物易于定制，并能够平衡基质保留和细胞渗透。天然聚合物包含固有的生物可识别的基序，增加了整合的病毒载体的治疗效果。重组聚合物使用高度保守的基序来仔细设计基质，允许进行精确的设计，包括载体保留和响应释放机制的元素。复合聚合物系统提供了创造具有独特性能的基质的机会。精心设计的骨架可以控制时空释放模式，与再生医学和抗肿瘤治疗中的方法协同。
Polymeric matrices inherently protect viral vectors from pre-existing immune conditions, limit dissemination to off-target sites, and can sustain vector release. Advancing methodologies in development of particulate based vehicles have led to improved encapsulation of viral vectors. Polymeric delivery systems have contributed to increasing cellular transduction, responsive release mechanisms, cellular infiltration, and cellular signaling. Synthetic polymers are easily customizable, and are capable of balancing matrix retention with cellular infiltration. Natural polymers contain inherent biorecognizable motifs adding therapeutic efficacy to the incorporated viral vector. Recombinant polymers use highly conserved motifs to carefully engineer matrices, allowing for precise design including elements of vector retention and responsive release mechanisms. Composite polymer systems provide opportunities to create matrices with unique properties. Carefully designed matrices can control spatiotemporal release patterns that synergize with approaches in regenerative medicine and antitumor therapies.