Altered default mode and fronto-parietal network subsystems in patients with schizophrenia and their unaffected siblings
Altered default mode and fronto-parietal network subsystems in patients with schizophrenia and their unaffected siblings
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精神分裂症患者及其未受影响的兄弟姐妹的默认模式和额顶网络子系统的改变
DOI：
10.1016/j.brainres.2014.03.024
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发表时间：
2014-05-08
期刊：
影响因子：
2.9
通讯作者：
Miao, Danmin
中科院分区：
文献类型：
--
作者：
Chang, Xiao;Shen, Hui;Miao, Danmin
精神分裂症的复杂症状最近被认为与神经回路中断和两个高阶内在大脑网络（默认模式网络（DMN）和额顶叶网络（FPN））的相应功能障碍有关。这些网络在功能上是异构的，并且由多个子系统组成。然而，这些子系统在多大程度上对疾病症状做出了不同的贡献，以及在未受影响的兄弟姐妹中发生这种异常的程度尚不清楚。我们使用静息状态功能MRI （rs-fMRI）检查了两个神经网络中子系统内部和相互连接的组间差异，样本包括精神分裂症患者（n=24），其未受影响的兄弟姐妹（n=25）和健康对照（n=22）。我们使用组独立成分分析（gICA）来识别四个网络子系统，包括DMN的前部和后部（aDMN, pDMN）以及FPN的左侧和右侧部分（lFPN, rFPN）。内连通性被定义为子系统内的神经一致性，而内连通性是指子系统之间的功能连通性。在内部连通性方面，患者和兄弟姐妹在aDMN和两个FPN子系统中共享连接障碍，而两组都保留了pDMN内的连通性。就互联性而言，所有组都表现出FPN和DMN子系统之间的积极联系，患者的rFPN和aDMN之间的相互作用甚至比对照组更强，这一特征可能是他们精神病症状的基础。我们的研究结果表明，DMN子系统对疾病风险表现出不同的责任，而FPN子系统表现出不同的互连改变。这些网络子系统之间的解离方式明确地提示了它们在疾病易感性和表现中的区别作用。(C) 2014 Elsevier B.V.版权所有
The complex symptoms of schizophrenia have recently been linked to disrupted neural circuits and corresponding malfunction of two higher-order intrinsic brain networks: The default mode network (DMN) and the fronto-parietal network (FPN). These networks are both functionally heterogeneous and consist of multiple subsystems. However, the extent to which these subsystems make differential contributions to disorder symptoms and to what degree such abnormalities occur in unaffected siblings have yet to be clarified. We used resting-state functional MRI (rs-fMRI) to examine group differences in intra- and inter-connectivity of subsystems within the two neural networks, across a sample of patients with schizophrenia (n=24), their unaffected siblings (n=25), and healthy controls (n=22). We used group independent component analysis (gICA) to identify four network subsystems, including anterior and posterior portions of the DMN (aDMN, pDMN) as well as left- and right-lateralized portions of the FPN (lFPN, rFPN). Intra-connectivity is defined as neural coherence within a subsystem whereas inter-connectivity refers to functional connectivity between subsystems. In terms of intra-connectivity, patients and siblings shared dysconnection within the aDMN and two FPN subsystems, while both groups preserved connectivity within the pDMN. In terms of inter-connectivity, all groups exhibited positive connections between FPN and DMN subsystems, with patients having even stronger interaction between rFPN and aDMN than the controls, a feature that may underlie their psychotic symptoms. Our results implicate that DMN subsystems exhibit different liabilities to the disease risk while FPN subsystems demonstrate distinct inter-connectivity alterations. These dissociating manners between network subsystems explicitly suggest their differentiating roles to the disease susceptibility and manifestation. (C) 2014 Elsevier B.V. All rights reserved.