Organophosphorus-Catalysed Staudinger Reduction
Organophosphorus-Catalysed Staudinger Reduction
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DOI：
10.1002/adsc.201100967
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发表时间：
2012-05-01
影响因子：
5.4
通讯作者：
van Delft, Floris L.
中科院分区：
文献类型：
--
作者：
van Kalkeren, Henri A.;Bruins, Jorick J.;van Delft, Floris L.
第一个在膦中催化的施陶丁格还原反应已经开发出来，显示出优异的产率和官能团选择性。为此，我们利用二苯并膦催化剂和中间体亚氨基正膦的温和原位还原。我们可以避免在还原过程中使用水，不会产生氧化膦废物，从而使产品的纯化变得容易。一系列叠氮化物被转化为胺，具有良好至优异的产率和高官能团耐受性。
The first Staudinger reduction that is catalytic in phosphine has been developed, showing excellent yields and functional group selectivity. To this end we utilised dibenzophosphole catalysts and mild in situ reduction of the intermediate iminophosphoranes. We could avoid the necessity of water during the reduction, obtained no phosphine oxides as waste and thus enabled facile purification of the product. A range of azides was converted into amines with good to excellent yields and high functional group tolerance.