Circadian preference links to depression in general adult population
Circadian preference links to depression in general adult population
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DOI：
10.1016/j.jad.2015.08.061
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发表时间：
2015-12-01
影响因子：
6.6
通讯作者：
Partonen, Timo
中科院分区：
文献类型：
--
作者：
Merikanto, Ilona;Kronholm, Erkki;Partonen, Timo
背景：在由相对较小的样本组成的早期研究中，倾向于将日常活动时间安排到傍晚时间与抑郁症的可能性更大相关。方法：在本研究中，我们使用来自2007年和2012年两项国家健康检查研究的10,503名年龄在25岁至74岁之间的芬兰成年人的联合基于人群的样本，分析了时型和抑郁症之间的关系。结果：我们的结果证实，在控制了一系列与抑郁症有关的和潜在的混杂因素后，我们的结果证实，晚上与诊断为抑郁障碍、抗抑郁药物治疗和抑郁症状(p<；每个0.0001)的几率增加显著相关。不考虑抑郁症状，晚型者的收缩压和舒张压较低，腰围较小，体重低于其他时型。限制：我们研究的局限性是，对时型和关于抑郁症的信息的评估仅基于自我报告信息，但基于全国健康体检调查的大样本是我们研究的主要优势。结论：总结：我们的研究结果与先前小样本研究的结果一致，证实了夜型者比其他时型有更高的抑郁风险。即使在那些睡眠充足的晚间人士中，这种风险也会增加。(C)2015爱思唯尔B.V.保留所有权利。
Background: Preference to time the daily activities towards the evening hours has been associated with a greater likelihood for depression in earlier studies consisting of relatively small samples.Methods: In the current study, we analyzed the relationship between chronotype and depression using a combined population-based sample of 10,503 Finnish adults aged 25 to 74 years from the two national FINRISK 2007 and 2012 health examination studies.Results: Our results confirmed that eveningness was significantly associated with the increased odds for a diagnosed depressive disorder, antidepressant medication, and depressive symptoms (p < 0.0001 for each), after controlling for a range of depression-attributed and potential confounding factors. Regardless of depressive symptoms, Evening-types had lower systolic and diastolic blood pressures, a smaller waist circumference, and a lower body weight than other chronotypes.Limitations: A limitation to our study is that the assessment of chronotype and information about depression was based on the self-report information only However, the big population-based sample, which is derived from a national health examination survey, is a major strength of our study.Conclusions: In conclusion, our study is in line the results from the previous, smaller sample size studies confirming that Evening-types have higher risk for depression than other chronotypes. This risk is elevated even among those Evening-types with sufficient amount of sleep. (c) 2015 Elsevier B.V. All rights reserved.