Immune Tolerance for Autoimmune Disease and Cell Transplantation.
Immune Tolerance for Autoimmune Disease and Cell Transplantation.
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DOI：
10.1146/annurev-bioeng-110315-020137
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发表时间：
2016-07-11
影响因子：
9.7
通讯作者：
Shea LD
中科院分区：
文献类型：
--
作者：
Luo X;Miller SD;Shea LD
免疫系统对内源性或移植的健康细胞的不期望的破坏导致组织功能的丧失或限制恢复组织功能的策略。目前的治疗通常涉及非特异性免疫抑制，其可能阻止对抗原的适当应答，从而降低体液免疫并增加患者对机会性感染、病毒再活化和瘤形成的易感性的风险。诱导抗原特异性免疫耐受以阻断对自身或同种异体抗原的不期望的免疫应答，同时保持剩余免疫系统的完整性，具有改变自身免疫性疾病的当前治疗的潜力，并作为基于细胞移植的疗法的关键使能技术。
The undesired destruction of healthy cells, either endogenous or transplanted, by the immune system results in the loss of tissue function or limits strategies to restore tissue function. Current therapies typically involve non-specific immunosuppression that may prevent the appropriate response to an antigen, thereby decreasing humoral immunity and increasing the risks of patient susceptibility to opportunistic infections, viral reactivation, and neoplasia. The induction of antigen-specific immunological tolerance to block undesired immune responses to self- or allogeneic antigens, while maintaining the integrity of the remaining immune system, has the potential to transform the current treatment of autoimmune disease and serve as a key enabling technology for therapies based on cell transplantation.