Polyamines, molecules necessary for cell division, colocalize with peptide growth factors.
Polyamines, molecules necessary for cell division, colocalize with peptide growth factors.
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多胺是细胞分裂所必需的分子，与肽生长因子共定位。
DOI：
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发表时间：
1989
影响因子：
6.6
通讯作者：
L. Larsson
中科院分区：
文献类型：
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作者：
D. Hougaard;L. Larsson
天然存在的多胺、亚精胺和精胺是细胞分裂和生长所必需的。通过再染色实验，使用三个独立的多胺细胞化学方法，连同肽免疫细胞化学，我们表明，大量的多胺发生在一些肽生长因子生产细胞类型。这些细胞包括产生表皮生长因子（EGF）的下颌下颗粒曲管细胞、产生胰岛素的胰岛细胞和产生生长激素（GH）的垂体前叶细胞。这些组织中的其他细胞类型仅显示弱的或没有多胺反应性。此外，已知含有血小板衍生生长因子（PDGF）的血小板对多胺也有强烈的染色。此外，在EGF细胞、胰岛素细胞和血小板中，多胺明显定位于分泌颗粒中。多胺可能是coreleased，并与肽生长因子的合作行动的可能性进行了讨论。
The naturally occurring polyamines spermidine and spermine are necessary for cell division and growth. By restaining experiments, using three independent polyamine cytochemical methods, together with peptide immunocytochemistry, we show that substantial amounts of polyamines occur in a number of peptide growth factor-producing cell types. These include submandibular granular convoluted duct cells producing epidermal growth factor (EGF), pancreatic islet cells producing insulin and anterior pituitary cells producing growth hormone (GH). Other cell types in these tissues display only weak or no polyamine reactivity. Also blood platelets, known to contain platelet-derived growth factor (PDGF), are strongly stained for polyamines. Moreover, in EGF cells, insulin cells and blood platelets, polyamines are clearly localized in secretory granules. The possibility that polyamines may be coreleased and act in concert with peptide growth factors is discussed.