Green tea: Health benefits as cancer preventive for humans
Green tea: Health benefits as cancer preventive for humans
复制标题
DOI：
10.1002/tcr.20039
复制
发表时间：
2005-01-01
期刊：
影响因子：
6.6
通讯作者：
Fujiki, H
中科院分区：
文献类型：
--
作者：
Fujiki, H
绿茶在日本是公认的防癌药物。这篇综述文章的目的是发展人类用绿茶饮料预防癌症的概念，这在很大程度上是我们的独家研究领域。本文简要回顾了几个主题，首先介绍了我们对五- o -没食子- β - d -葡萄糖和(-)-表没食子儿茶素没食子酸酯（EGCG）的初步研究，EGCG是绿茶提取物的主要成分。讨论了EGCG的作用机制，特别是减少tnf - α，我们展示了如何使用H-3-EGCG揭示了癌症预防的广泛靶器官。在埼玉县进行的一项流行病学研究的结果使我们能够确定绿茶的防癌量——每天10杯日本大小的茶，大约2.5克绿茶提取物——这使我们能够介绍用绿茶预防癌症的两阶段策略。第一阶段是延缓一般人群的癌症发病。第二阶段是癌症治疗后预防癌症复发。事实证明，把绿茶和防癌药物结合起来预防癌症对每天都喝绿茶的日本人特别有益。最后，吉姆·沃森教授激动人心的评论鼓舞了绿茶科学家。(c) 2005日本化学期刊论坛和Wiley期刊公司。
Green tea is an acknowledged cancer preventive in Japan. The aim of this review article is to develop the concept of cancer prevention with green tea beverage for humans, which has largely been our exclusive research territory. This paper briefly reviews several topics, beginning with the introduction of our initial work on penta-O-galloyl-beta-D-glucose and (-)-epigallocatechin gallate (EGCG), the main constituent of green tea extract. The mechanisms of EGCG action, particularly the reduction of TNF-alpha are discussed, and we show how use of H-3-EGCG revealed a wide range of target organs for cancer prevention. The results of an epidemiological study in Saitama Prefecture allowed us to determine the cancer preventive amount of green tea-10 Japanese-size cups per day, about 2.5 g green tea extract-which made it possible for us to introduce the two-stage strategy of cancer prevention with green tea. The first stage is the delay of cancer onset for the general population. The second stage is the prevention of recurrence of cancer for patients following cancer treatment. Combination cancer prevention with green tea and cancer preventive drugs is proving especially beneficial for Japanese, who drink green tea every day. And finally, the stimulating comments of Prof. Jim Watson have encouraged green tea scientists. (c) 2005 The Japan Chemical Journal Forum and Wiley Periodicals, Inc.